ArticleJournal of Parkinson's disease2021
Early-Onset Parkinsonism and Early-Onset Parkinson's Disease: A Population-Based Study (2010-2015).
Article in Journal of Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Cumulative incidence and risk factors of dementia in Parkinson's disease and parkinsonism: a population-based study.Brain communications · 2026Article
- Mortality risk associated with acetylcholinesterase inhibitor use in Parkinson's disease dementia according to sex and age at disease onset: a nationwide cohort study.Epidemiology and health · 2026Article
- Global, Regional, and National Burdens of Parkinson's Disease in Adults Aged 20-50 Years, 1990-2021: A Cross-Sectional Study.Health science reports · 2025Article
- Analysis of National Sample Cohort From Korea for Epidemiological and Prognostic Aspects of Parkinson's Disease According to Time of Onset.Journal of Korean medical science · 2025Article
- Network based approach for drug target identification in early onset Parkinson's disease.Scientific reports · 2025Article
- Mapping the global burden of early-onset Parkinson's disease: socioeconomic and regional inequalities from the Global Burden of Disease Study 2021.Frontiers in public health · 2025Article
- Unmet Need in Early-Onset Parkinson's Disease: Deep Brain Stimulation and Pregnancy.Journal of Parkinson's disease · 2024Review
- The impact of fatigue severity and depression level on the quality of life in individuals with Parkinson's disease in Taiwan.Frontiers in psychiatry · 2024Article
- A rare case of early onset lewy body dementia with parkinsonism associated with chronic exposure to copper contaminated drinking water.Frontiers in toxicology · 2024Review
- Early Levodopa-Induced Motor Complications in RAB39B X-Linked Parkinsonism.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Assessing the impact of novel risk loci on Alzheimer's and Parkinson's diseases in a Chinese Han cohort.Frontiers in neurology · 2024Article
- Ethnicity and Parkinson's Disease: Motor and Nonmotor Features and Disease Progression in Latino Patients Living in Rural California.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Beta-propeller protein-associated neurodegeneration: A clinical update with a case report.eNeurologicalSci · 2023Article
- Shared molecular genetic factors influence subcortical brain morphometry and Parkinson's disease risk.NPJ Parkinson's disease · 2023Article
- The Frequency of Korean Patients With Parkinson's Disease Carrying GBA Mutations in a Subgroup With Age at Onset ≤ 55 Years Old.Journal of movement disorders · 2023Article
- Using the cell phone while standing or walking affects balance and mobility in people with Parkinson's disease.Arquivos de neuro-psiquiatria · 2023Article
- Sleep Disorders in Early-Onset Parkinsonism: A Population-Based Study.Journal of Parkinson's disease · 2023Article
- The impact of China's zero markup drug policy on drug costs for managing Parkinson's disease and its complications: an interrupted time series analysis.Frontiers in public health · 2023Article
- 40-Year Incidence of Early-Onset Parkinson's Disease in Southeast Minnesota.Journal of Parkinson's disease · 2023Article
- Comparison of disability level between Early and Late Onset Parkinson's Disease using WHODAS 2.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEarly-onset Parkinson's disease (EOPD), occurring between ages 40 and 55, carries social, societal, and personal consequences and may progress, with fewer comorbidities than typical, later-onset disease.
objectiveTo examine the incidence and survival of EOPD and other Parkinsonism occurring before age 55 in the population-based cohort of residents in seven Minnesota counties.
methodsA movement-disorder specialist reviewed all the medical records in a 2010-2015 Parkinsonism-incident cohort to confirm diagnosis and subtypes.
resultsWe identified 27 patients diagnosed at ≤ 50 years with incident Parkinsonism 2010-15:11 (41%) cases of EOPD, 13 (48%) drug-induced Parkinsonism, and 3 (11%) other Parkinsonism; we also identified 69 incident cases of Parkinsonism ≤ 55 years, of which 28 (41%) were EOPD, 28 (41%) DIP, and 13 (19%) other Parkinsonism. Overall incidence for Parkinsonism ≤ 50 years was 1.98/100,000 person-years, and for EOPD was 0.81/100,000 person-years. In patients ≤ 55 years, Parkinsonism incidence was 5.05/100,000 person-years: in EOPD, 2.05/100,000 person-years. Levodopa-induced dyskinesia was present in 45%of EOPD (both ≤ 50 years and ≤ 55 years). Onset of cardinal motor symptoms was proximate to the diagnosis of EOPD, except for impaired postural reflexes, which occurred later in the course of EOPD. Among the 69 Parkinsonism cases ≤ 55 years, 9 (13%; all male) were deceased (only 1 case of EOPD). Men had a higher mortality risk compared to women (p = 0.049).
conclusionThe incidence of EOPD ≤ 50 years was 0.81/100,000 person-years (1.98 in Parkinsonism all type); prior to ≤ 55 years was 2.05/100,000 person-years (5.05 in Parkinsonism all type) with higher incidence in men than women. Men with Parkinsonism, all type, had higher mortality compared to women.
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