Evidence map›Paper›PMID 33720827›Full record

ArticleHealthcare policy = Politiques de sante2021

Understanding the Feasibility of Implementing CAR T-Cell Therapies from a Canadian Perspective.

Kristina Ellis, Kelly Grindrod, Stephen Tully, Tom McFarlane, Kelvin K W Chan, William W L Wong

Abstract read
In one paragraph

Article in Healthcare policy = Politiques de sante, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. CAR T-cell Therapy for Diffuse Large B-cell Lymphoma in Canada: A Cost-Utility Analysis.Medical decision making : an international journal of the Society for Medical Decision Making · 2024
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kristina EllisGraduate Student, School of Pharmacy, University of Waterloo, Waterloo, ON.
Kelly GrindrodAssociate Professor, School of Pharmacy, University of Waterloo, Waterloo, ON.
Stephen TullyPostdoctoral Fellow, School of Pharmacy, University of Waterloo, Waterloo, ON.
Tom McFarlaneClinical Lecturer, School of Pharmacy, University of Waterloo, Waterloo, ON; Clinical Oncology Pharmacist, Sunnybrook Odette Cancer Centre, Toronto, ON.
Kelvin K W ChanMedical Oncologist, Sunnybrook Odette Cancer Centre, Toronto, ON.
William W L WongAssistant Professor, School of Pharmacy, University of Waterloo, Waterloo, ON.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Canada, chimeric antigen receptor (CAR) T-cell therapy was recommended for funding for the treatment of select hematological cancers. Canadian hospitals have limited experience and capacity in administrating this therapy. We conducted a qualitative interview-based study with stakeholders in Canada. Questions were asked related to the development, administration, implementation and logistical planning of CAR T-cell therapy. Results were summarized into four main themes: (i) novel; (ii) patient characteristics and the delivery of care; (iii) processes from "bench-to-bedside"; and (iv) the future state, including both challenges and recommendations to ensure sustainability. Valuable perspectives from stakeholders highlight some of the unique challenges to implementing a highly personalized and expensive-to-deliver therapy.

Indexed as

Immunotherapy, AdoptiveReceptors, Chimeric AntigenCanadaFeasibility StudiesHumansReceptors, Chimeric Antigen

Identifiers

PMID33720827
PMCPMC7957352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.