Evidence map›Paper›PMID 33720456›Full record

ArticleThe Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association2022

Health-related quality of life in head and neck cancer survivors: Evaluating the rural disadvantage.

Jenna L Adamowicz, Alan Christensen, M Bryant Howren, Aaron T Seaman, Nicholas D Kendell, Shylo Wardyn, Nitin A Pagedar

Abstract read
In one paragraph

Article in The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Social determinants of health in studies using PROMs to assess toxicities associated with immune checkpoint inhibitor treatment: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
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  10. Disparities in Care for Patients with Head and Neck Cancer.Surgical oncology clinics of North America · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jenna L AdamowiczVA Office of Rural Health, Veterans Rural Health Resource Center - Iowa City, Iowa City VA Health Care System, Iowa City, Iowa, USA.ORCID 0000-0002-1468-789X
Alan ChristensenVA Office of Rural Health, Veterans Rural Health Resource Center - Iowa City, Iowa City VA Health Care System, Iowa City, Iowa, USA.
M Bryant HowrenVA Office of Rural Health, Veterans Rural Health Resource Center - Iowa City, Iowa City VA Health Care System, Iowa City, Iowa, USA.ORCID 0000-0002-5863-3420
Aaron T SeamanVA Office of Rural Health, Veterans Rural Health Resource Center - Iowa City, Iowa City VA Health Care System, Iowa City, Iowa, USA.
Nicholas D KendellDepartment of Otolaryngology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Shylo WardynVA Office of Rural Health, Veterans Rural Health Resource Center - Iowa City, Iowa City VA Health Care System, Iowa City, Iowa, USA.
Nitin A PagedarDepartment of Otolaryngology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
The University of Iowa Clinical and Translational Science AwardKL2TR002536 · NCATS · UNIVERSITY OF IOWA · PI BASSUK, ALEXANDER G · 2018 to 2022
$3.3M
Mechanisms of Health and Disease at the Behavioral-Biomedical InterfaceT32GM108540 · NIGMS · UNIVERSITY OF IOWA · PI LUTGENDORF, SUSAN K, VOSS, MICHELLE WEBB · 2014 to 2023
$1.7M
NCATS NIH HHS KL2 TR002536NIGMS NIH HHS T32 GM108540
6 · The paper itself

Abstract

purposeHead and neck cancer (HNC) survivors often experience distress and health-related quality of life (HRQOL) impairment. Research suggests that rural cancer patients may have poorer outcomes than urban patients. This study examined whether HNC patient emotional and HRQOL outcomes differ in those living in a rural versus urban location at 6 and 12 months postdiagnosis.

methodsA total of 261 HNC patients were included from a longitudinal study of HNC outcomes. The majority were diagnosed with advanced stage cancer (51.3%); the most common cancer site was oral cavity (41.0%). Rurality was measured using the US Department of Agriculture Rural Urban Commuting Area codes. Depression was measured using the Beck Depression Inventory (BDI), general HRQOL using the Short Form-36 (SF-36), and HNC-specific HRQOL using the Head and Neck Cancer Inventory (HNCI). Analyses were 2 (group) × 3 (assessment) repeated measures ANCOVAs, controlling for demographic and clinical characteristics.

findingsApproximately 45% of the sample lived in a rural location. Follow-up comparisons of significant overall models indicated that rural patients reported significantly more nonsomatic depression symptoms at 6-month follow-up. Rural patients were also more likely to report significantly poorer general mental HRQOL at 12-month follow-up, significantly poorer HNC-specific HRQOL related to eating at 6- and 12-month follow-up, and marginally worse aesthetics at 12-month follow-up.

conclusionsThese findings are consistent with suggestions that rural HNC patients may be at heightened risk for depression symptoms and decrements in HRQOL. Patients should be screened and regularly monitored for issues with depression and HNC-specific HRQOL throughout the survivorship period.

Indexed as

Head and Neck NeoplasmsQuality of LifeHumansLongitudinal StudiesRural PopulationSurvivorscancer survivorshipdepressionhead and neck cancerhealth-related quality of liferurality

Identifiers

PMID33720456
PMCPMC8477149

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.