ArticleeLife2021
Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Pairwise genetic meta-analyses between schizophrenia and substance dependence phenotypes reveals novel association signals with pharmacological significance.Translational psychiatry · 2022Pooled it
- The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness.Nature communications · 2022Pooled it
- Evaluation of silicosis combined with type 2 diabetes mellitus based on the quantitative CT measured parameters.Quantitative imaging in medicine and surgery · 2025Article
- Genomic network analysis characterizes genetic architecture and identifies trait-specific biology.medRxiv : the preprint server for health sciences · 2024Article
- Using Genetics to Inform Interventions Related to Sodium and Potassium in Hypertension.Circulation · 2024Observational
- Genetic influences on circulating retinol and its relationship to human health.Nature communications · 2024Article
- Genetics-informed precision treatment formulation in schizophrenia and bipolar disorder.American journal of human genetics · 2022Article
- Variation in cardiovascular disease risk factors among older adults in the Hunter Community Study cohort: A comparison of diet quality versus polygenic risk score.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022Article
- Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders.Science advances · 2022Article
- Advancing the use of genome-wide association studies for drug repurposing.Nature reviews. Genetics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Measures of lung function are heritable, and thus, we sought to utilise genetics to propose drug-repurposing candidates that could improve respiratory outcomes. Lung function measures were found to be genetically correlated with seven druggable biochemical traits, with further evidence of a causal relationship between increased fasting glucose and diminished lung function. Moreover, we developed polygenic scores for lung function specifically within pathways with known drug targets and investigated their relationship with pulmonary phenotypes and gene expression in independent cohorts to prioritise individuals who may benefit from particular drug-repurposing opportunities. A transcriptome-wide association study (TWAS) of lung function was then performed which identified several drug-gene interactions with predicted lung function increasing modes of action. Drugs that regulate blood glucose were uncovered through both polygenic scoring and TWAS methodologies. In summary, we provided genetic justification for a number of novel drug-repurposing opportunities that could improve lung function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.