ArticleeLife2021
Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis.
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Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- Cytotoxic CD4Signal transduction and targeted therapy · 2026Review
- Cellular signaling meets bacterial infection: the integrative role of STAT3.Frontiers in cellular and infection microbiology · 2026Review
- Prolonged Wnt3a exposure tolerizes macrophages to inflammatory stimuli.Frontiers in immunology · 2026Article
- Inflammation in cardiovascular-kidney-metabolic syndrome: key roles and underlying mechanisms-a comprehensive review.Molecular and cellular biochemistry · 2025Review
- Review
- Crosstalk Between Allergic Inflammation and Autophagy.International journal of molecular sciences · 2025Review
- How lactate and lactylation shape the immunity system in atherosclerosis (Review).International journal of molecular medicine · 2025Review
- Caloric restriction promotes resolution of atherosclerosis in obese mice, while weight regain accelerates its progression.The Journal of clinical investigation · 2025Article
- Inflammation reprogramming and immunomodulation: Next-generation treatments for atherosclerosis.Cell reports. Medicine · 2025Review
- Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances.Signal transduction and targeted therapy · 2025Review
- Wnt 3a-Modified Scaffolds Improve Nerve Regeneration by Boosting Schwann Cell Function.ACS applied materials & interfaces · 2024Article
- Article
- Article
- Immune cell-mediated features of atherosclerosis.Frontiers in cardiovascular medicine · 2024Review
- Cells in Atherosclerosis: Focus on Cellular Senescence from Basic Science to Clinical Practice.International journal of molecular sciences · 2023Review
- IL-4 and IL-13 induce equivalent expression of traditional M2 markers and modulation of reactive oxygen species in human macrophages.Scientific reports · 2023Article
- Endothelial Dysfunction in Cardiorenal Conditions: Implications of Endothelial Glucocorticoid Receptor-Wnt Signaling.International journal of molecular sciences · 2023Review
- Review
- Advances in the role of STAT3 in macrophage polarization.Frontiers in immunology · 2023Review
- The diverse roles of macrophages in metabolic inflammation and its resolution.Frontiers in cell and developmental biology · 2023Review
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 2 countries.
Ada WeinstockDepartment of Medicine, Leon H. Charney Division of Cardiology, Cardiovascular Research Program, New York University Grossman School of Medicine, New York, United States.ORCID 0000-0003-3619-3388
Karishma RahmanDepartment of Medicine, Leon H. Charney Division of Cardiology, Cardiovascular Research Program, New York University Grossman School of Medicine, New York, United States.
Or YaacovDepartment of Medicine, Leon H. Charney Division of Cardiology, Cardiovascular Research Program, New York University Grossman School of Medicine, New York, United States.ORCID 0000-0002-8496-2607
Hitoo NishiDepartment of Medicine, Leon H. Charney Division of Cardiology, Cardiovascular Research Program, New York University Grossman School of Medicine, New York, United States.
Prashanthi MenonDepartment of Medicine, Leon H. Charney Division of Cardiology, Cardiovascular Research Program, New York University Grossman School of Medicine, New York, United States.
Cyrus A NikainDepartment of Medicine, Leon H. Charney Division of Cardiology, Cardiovascular Research Program, New York University Grossman School of Medicine, New York, United States.
Michela L GarabedianDepartment of Medicine, Leon H. Charney Division of Cardiology, Cardiovascular Research Program, New York University Grossman School of Medicine, New York, United States.
Stephanie PenaDepartment of Medicine, Leon H. Charney Division of Cardiology, Cardiovascular Research Program, New York University Grossman School of Medicine, New York, United States.
Naveed AkbarDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Brian E SansburyCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
Sean P HeffronDepartment of Medicine, Leon H. Charney Division of Cardiology, Cardiovascular Research Program, New York University Grossman School of Medicine, New York, United States.
Jianhua LiuDepartment of Surgery, Mount Sinai School of Medicine, New York, United States.
Gregory MareckiDepartment of Medicine, Leon H. Charney Division of Cardiology, Cardiovascular Research Program, New York University Grossman School of Medicine, New York, United States.
Dawn FernandezCardiovascular Research Center, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States.
Emily J BrownDepartment of Medicine, Leon H. Charney Division of Cardiology, Cardiovascular Research Program, New York University Grossman School of Medicine, New York, United States.
Kelly V RugglesDivision of Translational Medicine, Department of Medicine, New York University Langone Health, Institute for Systems Genetics, New York University Grossman School of Medicine, New York, United States.ORCID 0000-0002-0152-0863
Stephen A RamseyDepartment of Biomedical Sciences, School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, United States.
Chiara GiannarelliCardiovascular Research Center, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States.
Matthew SpiteCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
Robin P ChoudhuryDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
P'ng LokeAcute Vascular Imaging Centre, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-6211-3292
Edward A FisherDepartment of Medicine, Leon H. Charney Division of Cardiology, Cardiovascular Research Program, New York University Grossman School of Medicine, New York, United States.ORCID 0000-0001-9802-143X
New York University · USBrigham and Women's Hospital · USIcahn School of Medicine at Mount Sinai · USUniversity of Oxford · GBNational Institutes of Health · USOregon State University · US
Funding
MEDICAL SCIENTIST TRAININGT32GM007308 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PHILIPS, MARK REID · 1985 to 2019
$23.2MResolution Mechanisms in Acute Inflammation: Resolution PharmacologyP01GM095467 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 2011 to 2020
$14.8MMolecular Regulation of Atherosclerosis Regression - RenewalR01HL084312 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FISHER, EDWARD A · 2006 to 2024
$11.4MTRAINING PROGRAM IN MOLECULAR AND CELLULAR CARDIOLOGYT32HL007824 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GELB, BRUCE D · 1995 to 2022
$8.6MAlternatively activated macrophages during type 2 immune responsesZIAAI001256 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LOKE, P'NG · 2020 to 2025
$6.1MTraining Program in Cardiovascular SciencesT32HL098129 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Glenn I Fishman, Ira J Goldberg · 2009 to 2026
$5.9MRole of Inflammation-Resolving Lipid Mediators In Ischemic RevascularizationR01HL106173 · NHLBI · UNIVERSITY OF LOUISVILLE · PI SPITE, MATTHEW R · 2011 to 2023
$5.7MTraining Program in Immunology and Inflammation.T32AI100853 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Susan Ruth Schwab · 2012 to 2026
$4.5MInteractions between helminth colonization and the gut microbiotaR01AI130945 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA · 2018 to 2022
$3.3MAlternatively activated macrophages during helminth infectionR01AI133977 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TORRES, VICTOR J. · 2017 to 2021
$2.4MMechanisms underlying caloric restriction-mediated resolution of atherosclerosisR00HL151963 · NHLBI · UNIVERSITY OF CHICAGO · PI WEINSTOCK, ADA · 2022 to 2024
$922kRole of alternatively spliced Tissue Factor in atherosclerosisK23HL111339 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GIANNARELLI, CHIARA · 2013 to 2017
$782kAmerican Heart Association-American Stroke Association 18POST34080390British Heart Foundation PG/18/53/33895NCATS NIH HHS R21 TR001739NCATS NIH HHS UH2 TR002067NCATS NIH HHS UH3 TR002067NHLBI NIH HHS 5T23HL007824NHLBI NIH HHS F30 HL131183NHLBI NIH HHS F30HL131183NHLBI NIH HHS F32 HL136044NHLBI NIH HHS K23 HL111339NHLBI NIH HHS K23 HL135398NHLBI NIH HHS K99 HL151963NHLBI NIH HHS K99HL151963NHLBI NIH HHS R00 HL151963NHLBI NIH HHS R01 HL084312NHLBI NIH HHS R01 HL106173NHLBI NIH HHS R03HL13528NHLBI NIH HHS T32 HL007824NHLBI NIH HHS T32 HL098129NIAID NIH HHS R01 AI130945NIAID NIH HHS R01 AI133977NIAID NIH HHS T32 AI100853NIGMS NIH HHS P01 GM095467NIGMS NIH HHS T32 GM007308NIH HHS T32GM007308
Abstract
Atherosclerosis is a disease of chronic inflammation. We investigated the roles of the cytokines IL-4 and IL-13, the classical activators of STAT6, in the resolution of atherosclerosis inflammation. Using
Indexed as
Wnt Signaling PathwayAnimalsAtherosclerosisDose-Response Relationship, DrugFemaleHumansInterleukin-4MacrophagesMaleMiceInterleukin-4atherosclerosis resolutionhumanIL4immunologyinflammationmacrophagesmedicinemousepge2STAT3Wnt
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.