Evidence map›Paper›PMID 33719576›Full record

ArticleAmerican journal of physiology. Renal physiology2021

Roles of WNK4 and SPAK in K

Anindit Mukherjee, Chao-Ling Yang, James A McCormick, Kevin Martz, Avika Sharma, David H Ellison

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Thirty years of the NaCl cotransporter: from cloning to physiology and structure.American journal of physiology. Renal physiology · 2023
    Review
  5. Review
  6. Review
  7. Article
  8. Potassium homeostasis: sensors, mediators, and targets.Pflugers Archiv : European journal of physiology · 2022
    Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Anindit MukherjeeDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
Chao-Ling YangDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
James A McCormickDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.ORCID 0000-0003-4000-6653
Kevin MartzDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
Avika SharmaDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
David H EllisonDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.ORCID 0000-0003-2915-265X
Oregon Health & Science University · US

Funding

WNK Kinase Regulation of Thiazide-sensitive NaCl TransportR01DK051496 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI David Hoadley Ellison, CHAO-LING YANG · 1998 to 2026
$8.4M
Role of Kir4.1 in Regulating NCC and ROMK in DCTR01DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2001 to 2020
$7.4M
Regulation of sodium transport and blood pressure by SPAK/OSR1 kinasesR01DK098141 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI JAMES A MCCORMICK, Ujwal Shinde · 2014 to 2026
$4.2M
Renal Effects of AldosteroneI01BX002228 · VA · PORTLAND VA MEDICAL CENTER · PI ELLISON, DAVID H · 2014 to 2021
–
BLRD VA I01 BX002228HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK054196HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK054983NIDDK NIH HHS R01 DK051496NIDDK NIH HHS R01 DK054983NIDDK NIH HHS R01 DK098141U.S. Department of Veterans Affairs (VA) 1I01BX002228
6 · The paper itself

Abstract

Phosphorylation of the thiazide-sensitive NaCl cotransporter (NCC) in the distal convoluted tubule (DCT) is altered rapidly in response to changes in extracellular K

Indexed as

AnimalsChloridesHEK293 CellsHumansKidney Tubules, DistalKineticsMaleMiceMice, Inbred C57BLMice, KnockoutPhosphorylationPotassium, DietaryProtein Serine-Threonine KinasesProtein TransportSolute Carrier Family 12, Member 3ChloridesOXSR1 protein, mousePotassium, DietaryPrkwnk4 protein, mouseProtein Serine-Threonine KinasesSLC12A3 protein, humanSlc12a3 protein, mouseSolute Carrier Family 12, Member 3STK39 protein, humanStk39 protein, mouseWNK4 protein, humanhyperkalemiaphosphatasepotassiumthiazidetransport

Identifiers

PMID33719576
PMCPMC8174808
OpenAlexW3139362520

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.