Evidence map›Paper›PMID 33719520›Full record

ArticleEpigenomics2021

A transdisciplinary approach to understand the epigenetic basis of race/ethnicity health disparities.

Lucas A Salas, Lauren C Peres, Zaneta M Thayer, Rick Wa Smith, Yichen Guo, Wonil Chung, Jiahui Si, Liming Liang

Abstract read
In one paragraph

Article in Epigenomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
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  8. Inequity in Cancer and Cancer Care Delivery in the United States.Hematology/oncology clinics of North America · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Research Silos in Cancer Disparities: Obstacles to Improving Clinical Outcomes for Underserved Patient Populations.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  16. Article
  17. Review
  18. Hypertension Impacts Peripheral Blood Leukocyte Composition.Hypertension (Dallas, Tex. : 1979) · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lucas A SalasDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, Lebanon, NH 03756, USA.ORCID 0000-0002-2279-4097
Lauren C PeresDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.ORCID 0000-0002-6620-8600
Zaneta M ThayerDepartment of Anthropology, Dartmouth College, Hanover, NH 03755, USA.ORCID 0000-0001-8028-942X
Rick Wa SmithDepartment of Anthropology, Dartmouth College, Hanover, NH 03755, USA.
Yichen GuoMerck & Co., Inc, Boston, MA 02115, USA.
Wonil ChungDepartment of Statistics & Actuarial Science, Soongsil University, Seoul, 06478, Korea.ORCID 0000-0002-5766-6247
Jiahui SiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Liming LiangProgram in Genetic Epidemiology & Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0001-8261-3174

Funding

Relation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI SALAS DIAZ, LUCAS A · 2013 to 2022
$23.7M
The Role of Inflammation in the Racial Disparities in Ovarian Cancer SurvivalR00CA218681 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI PERES, LAUREN COLE · 2018 to 2020
$722k
NCI NIH HHS R00 CA218681NIGMS NIH HHS P20 GM104416
6 · The paper itself

Abstract

Health disparities correspond to differences in disease burden and mortality among socially defined population groups. Such disparities may emerge according to race/ethnicity, socioeconomic status and a variety of other social contexts, and are documented for a wide range of diseases. Here, we provide a transdisciplinary perspective on the contribution of epigenetics to the understanding of health disparities, with a special emphasis on disparities across socially defined racial/ethnic groups. Scientists in the fields of biological anthropology, bioinformatics and molecular epidemiology provide a summary of theoretical, statistical and practical considerations for conducting epigenetic health disparities research, and provide examples of successful applications from cancer research using this approach.

Indexed as

EthnicityRacial GroupsEpigenesis, GeneticEpigenomicsHumansSocial Classanthropologycancer health disparitiescomputational biologyDNA methylationepigenomicsethnic groupshealth status disparitiesmolecular epidemiology

Identifiers

PMID33719520
PMCPMC8579937

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.