Evidence map›Paper›PMID 33719511›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin.

Zachary S Clayton, Vienna E Brunt, David A Hutton, Abigail G Casso, Brian P Ziemba, Simon Melov, Judith Campisi, Douglas R Seals

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 35 citations in OpenAlex.

  1. Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Observational
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zachary S ClaytonDepartment of Integrative Physiology, University of Colorado Boulder, Colorado (Z.S.C., V.E.B., D.A.H., A.G.C., B.P.Z., D.R.S.).
Vienna E BruntDepartment of Integrative Physiology, University of Colorado Boulder, Colorado (Z.S.C., V.E.B., D.A.H., A.G.C., B.P.Z., D.R.S.).
David A HuttonDepartment of Integrative Physiology, University of Colorado Boulder, Colorado (Z.S.C., V.E.B., D.A.H., A.G.C., B.P.Z., D.R.S.).
Abigail G CassoDepartment of Integrative Physiology, University of Colorado Boulder, Colorado (Z.S.C., V.E.B., D.A.H., A.G.C., B.P.Z., D.R.S.).
Brian P ZiembaDepartment of Integrative Physiology, University of Colorado Boulder, Colorado (Z.S.C., V.E.B., D.A.H., A.G.C., B.P.Z., D.R.S.).
Simon MelovBuck Institute for Research on Aging, Novato, CA (S.M., J.C.).
Judith CampisiBuck Institute for Research on Aging, Novato, CA (S.M., J.C.).
Douglas R SealsDepartment of Integrative Physiology, University of Colorado Boulder, Colorado (Z.S.C., V.E.B., D.A.H., A.G.C., B.P.Z., D.R.S.).
University of Colorado Boulder · USBuck Institute for Research on Aging · US

Funding

TRAINING IN RENAL &ELECTROLYTE DISEASE &HYPERTENSIONT32DK007135 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JOHNSON, RICHARD JOSEPH, KENDRICK, JESSICA B · 1986 to 2024
$5.3M
Role of cellular senescence in cardiovascular agingR01AG055822 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI CAMPISI, JUDITH, MELOV, SIMON · 2018 to 2022
$4.9M
Mitochondrial oxidative stress: a target for treatment of doxorubicin-associated vascular endothelial dysfunctionF32HL151022 · NHLBI · UNIVERSITY OF COLORADO · PI CLAYTON, ZACHARY S. · 2020 to 2021
$89k
NHLBI NIH HHS F32 HL151022NIA NIH HHS R01 AG055822NIDDK NIH HHS T32 DK007135
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AnimalsAntineoplastic AgentsAortaCollagenDoxorubicinElastinExtracellular MatrixInflammationMaleMicePulse Wave AnalysisTumor Necrosis Factor-alphaVascular StiffnessAntineoplastic AgentsCollagenDoxorubicinElastinTumor Necrosis Factor-alphaanthracyclinescardiovascular diseasesdoxorubicinelastic modulusfibrosis

Identifiers

PMID33719511
PMCPMC8035245
OpenAlexW3137482685

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.