Evidence map›Paper›PMID 33719410›Full record

ArticleACS applied materials & interfaces2021

Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer.

Irene Villa, Chiara Villa, Roberta Crapanzano, Valeria Secchi, Massimo Tawfilas, Elena Trombetta, Laura Porretti, Andrea Brambilla, Marcello Campione, Yvan Torrente and 2 more

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Irene VillaDipartimento di Scienza dei Materiali, Università degli Studi Milano-Bicocca, via R. Cozzi 55, 20125 Milano, Italy.ORCID http://orcid.org/0000-0002-6150-7847
Chiara VillaStem Cell Laboratory, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, via F. Sforza 35, 20122 Milan, Italy.
Roberta CrapanzanoDipartimento di Scienza dei Materiali, Università degli Studi Milano-Bicocca, via R. Cozzi 55, 20125 Milano, Italy.
Valeria SecchiDipartimento di Scienza dei Materiali, Università degli Studi Milano-Bicocca, via R. Cozzi 55, 20125 Milano, Italy.
Massimo TawfilasDipartimento di Scienza dei Materiali, Università degli Studi Milano-Bicocca, via R. Cozzi 55, 20125 Milano, Italy.
Elena TrombettaServizio di Citofluorimetria, Laboratorio Analisi, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via F. Sforza 35, 20122 Milan, Italy.
Laura PorrettiServizio di Citofluorimetria, Laboratorio Analisi, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via F. Sforza 35, 20122 Milan, Italy.
Andrea BrambillaStem Cell Laboratory, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, via F. Sforza 35, 20122 Milan, Italy.
Marcello CampioneDipartimento di Scienze dell'Ambiente e della Terra, Università degli Studi Milano-Bicocca, Piazza della Scienza, 20126 Milano, Italy.ORCID http://orcid.org/0000-0001-5627-6186
Yvan TorrenteStem Cell Laboratory, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, via F. Sforza 35, 20122 Milan, Italy.
Anna VeddaDipartimento di Scienza dei Materiali, Università degli Studi Milano-Bicocca, via R. Cozzi 55, 20125 Milano, Italy.
Angelo MonguzziDipartimento di Scienza dei Materiali, Università degli Studi Milano-Bicocca, via R. Cozzi 55, 20125 Milano, Italy.ORCID http://orcid.org/0000-0001-9768-4573

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a model radio-photodynamic therapy (RPDT) agent, we developed a multicomponent nanomaterial by anchoring conjugated chromophores on the surface of scintillating chrysotile nanotubes. Its ultimate composition makes the system a scintillation-activated photosensitizer for the singlet oxygen production. This nanomaterial shows a remarkable ability to enhance the production of singlet oxygen in an aqueous environment, under X-ray irradiation, boosting its production by almost 1 order of magnitude. Its efficiency as a coadjutant for radiotherapy has been tested

Indexed as

NanotubesAsbestos, SerpentineCell Line, TumorHumansNeoplasmsPhotochemotherapyPhotosensitizing AgentsSinglet OxygenX-RaysAsbestos, SerpentinePhotosensitizing AgentsSinglet Oxygennanomaterialsphotodynamic therapyradiotherapyscintillating nanoparticlessinglet oxygen

Identifiers

PMID33719410
PMCPMC8153399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.