Evidence map›Paper›PMID 33719360›Full record

ArticleClinical practice and epidemiology in mental health : CP & EMH2020

Defining the Optimal Threshold Scores for Adult Autism Subthreshold Spectrum (AdAS Spectrum) in Clinical and General Population.

Liliana Dell'Osso, Claudia Carmassi, Ivan Mirko Cremone, Dario Muti, Antonio Salerni, Filippo Maria Barberi, Enrico Massimetti, Camilla Gesi, Pierluigi Politi, Eugenio Aguglia and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Clinical practice and epidemiology in mental health : CP & EMH, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Liliana Dell'OssoDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Claudia CarmassiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Ivan Mirko CremoneDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Dario MutiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Antonio SalerniDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Filippo Maria BarberiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Enrico MassimettiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Camilla GesiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Pierluigi PolitiDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Eugenio AgugliaDepartment of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy.
Mario MajDepartment of Psychiatry, University of Nalpes SUN, Naples, Italy.
Barbara CarpitaDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
University of Pisa · ITUniversity of Catania · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Adult Autism Subthreshold Spectrum (AdAS Spectrum) is a recently developed instrument tailored to assess the broad range of full-threshold as well as sub-threshold manifestations related to the autism spectrum. Although it has proved to be a valuable instrument for quantitative assessment of autistic symptoms, the AdAS Spectrum still lacks validated diagnostic thresholds.

objectiveThe aim of this study was to define the best cut-off scores of the AdAS Spectrum for determining the presence of subthreshold autistic traits as well as a clinically significant autism spectrum disorder (ASD).

methodsOur sample was composed of 39 patients with full-blown ASD, 73 subjects with autistic traits, and 150 healthy controls. Subjects were evaluated by trained psychiatrists, who performed a clinical diagnosis according to DSM-5 and then assessed with the AdAS Spectrum and the Autism Spectrum Quotient.

resultsOur results showed that the most discriminant cut-off scores were 70 for identifying subjects with full-blown ASD, and 43 for determining the presence of significant autistic traits.

conclusionThe threshold values proposed here showed satisfying levels of specificity and sensibility, as well as a good agreement with the diagnosis according to DSM-5 criteria, confirming the validity of the AdAS Spectrum as a psychometric tool for measuring ASD-related conditions in the clinical and general population.

Indexed as

AdAS SpectrumAutism Spectrum DisorderAutistic traitsDiagnostic thresholdPsychometric instrumentRAADS

Identifiers

PMID33719360
PMCPMC7931149
OpenAlexW3122628238

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.