ArticleFrontiers in genetics2021
Global Transcriptomic Analyses Reveal Genes Involved in Conceptus Development During the Implantation Stages in Pigs.
Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Estradiol-17β, a key embryonic signal, regulates gene expression and cellular functions in the porcine trophoblast.Biology of reproduction · 2026Article
- Identification and expression characteristics of porcine embryonic circRNAs during the peri-implantation.BMC genomics · 2026Article
- Conceptus Elongation, Implantation, and Early Placental Development in Species with Central Implantation: Pigs, Sheep, and Cows.Biomolecules · 2025Review
- Dynamic intrauterine crosstalk promotes porcine embryo implantation during early pregnancy.Science China. Life sciences · 2024Article
- Integrins and their potential roles in mammalian pregnancy.Journal of animal science and biotechnology · 2023Review
- Integrated analysis of transcriptome and metabolome revealed biological basis of sows from estrus to lactation.iScience · 2023Article
- Novel role for conceptus signals in mRNA expression regulation by DNA methylation in porcine endometrium during early pregnancy†.Biology of reproduction · 2023Article
- Early steps of embryo implantation are regulated by exchange of extracellular vesicles between the embryo and the endometrium.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Global analysis of differential gene expression within the porcine conceptus transcriptome as it transitions through spherical, ovoid, and tubular morphologies during the initiation of elongation.Molecular reproduction and development · 2022Article
- Revisiting the Transcriptome Landscape of Pig Embryo Implantation Site at Single-Cell Resolution.Frontiers in cell and developmental biology · 2022Article
- Integrated Insight into the Molecular Mechanisms of Spontaneous Abortion during Early Pregnancy in Pigs.International journal of molecular sciences · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal mortality remains a significant concern to the pig farming industry around the world. Spontaneous fetal loss ranging from 20 to 45% by term occur after fertilization, with most of the loss happening during the implantation period. Since the factors regulating the high mortality rates of early conceptus during implantation phases are poorly understood, we sought to analyze the overall gene expression changes during this period, and identify the molecular mechanisms involved in conceptus development. This work employed Illumina's next-generation sequencing (RNA-Seq) and quantitative real-time PCR to analyze differentially expressed genes (DEGs). Soft clustering was subsequently used for the cluster analysis of gene expression. We identified 8236 DEGs in porcine conceptus at day 9, 12, and 15 of pregnancy. Annotation analysis of these genes revealed rRNA processing (GO:0006364), cell adhesion (GO:1904874), and heart development (GO:0007507), as the most significantly enriched biological processes at day 9, 12, and 15 of pregnancy, respectively. In addition, we found various genes, such as T-complex 1, RuvB-like AAA ATPase 2, connective tissue growth factor, integrins, interferon gamma, SLA-1, chemokine ligand 9, PAG-2, transforming growth factor beta receptor 1, and Annexin A2, that play essential roles in conceptus morphological development and implantation in pigs. Furthermore, we investigated the function of PAG-2
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