ArticleDevelopmental medicine and child neurology2021
Microstructural changes in the spinal cord of adults with cerebral palsy.
Article in Developmental medicine and child neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 23 citations in OpenAlex.
- Modeling cerebral palsy in animals.Developmental medicine and child neurology · 2026Review
- The role of independent walking in the maturation of the spinal locomotor output in children with cerebral palsy.Frontiers in physiology · 2026Article
- Motor function and gait decline in individuals with cerebral palsy during adulthood: a narrative review of potential physiological determinants.European journal of applied physiology · 2024Review
- Contributions of the sensory system to motor learning : Focus on Cerebral Palsy.Pediatric research · 2024Article
- Linking corticospinal tract activation and upper-limb motor control in adults with cerebral palsy.Developmental medicine and child neurology · 2024Article
- A preliminary study on the spasticity reduction of quadriceps after selective dorsal rhizotomy in pediatric cases of spastic cerebral palsy.Acta neurochirurgica · 2024Article
- Disruption of Sensorimotor Cortical Oscillations by Visual Interference Predicts the Altered Motor Performance of Persons with Cerebral Palsy.Neuroscience · 2024Article
- Motor practice related changes in the sensorimotor cortices of youth with cerebral palsy.Brain communications · 2024Article
- Reduced brainstem volume is associated with mobility impairments in youth with cerebral palsy.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2023Article
- Inhibitory Synaptic Influences on Developmental Motor Disorders.International journal of molecular sciences · 2023Review
- Reduced Brainstem Volume is Associated with Mobility Impairments in Youth with Cerebral Palsy.Research square · 2023Article
- The confound of hemodynamic response function variability in human resting-state functional MRI studies.Frontiers in neuroscience · 2023Article
- Spinal cord microstructural changes are connected with the aberrant sensorimotor cortical oscillatory activity in adults with cerebral palsy.Scientific reports · 2022Article
- Reduced wrist flexor H-reflex excitability is linked with increased wrist proprioceptive error in adults with cerebral palsy.Frontiers in neurology · 2022Article
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4 authors at 1 institution in 1 country.
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Abstract
aimTo quantify the microstructural differences in the cervical-thoracic spinal cord of adults with cerebral palsy (CP).
methodMagnetic resonance imaging of the proximal spinal cord (C6-T3) was conducted on a cohort of adults with CP (n=13; mean age=31y 11mo, standard deviation [SD] 8y 7mo; range=20y 8mo-47y 6mo; eight females, five males) and population norm adult controls (n=16; mean age=31y 4mo, SD 9y 9mo; range=19y 4mo-49y 5mo; seven females, nine males). The cross-sectional area (CSA) of the spinal cord, gray and white matter, magnetization transfer ratio (MTR), and fractional anisotropy of the cuneatus and corticospinal tracts were calculated.
resultsThe total spinal cord CSA and proportion of the spinal cord gray matter CSA were significantly decreased in the adults with CP. The corticospinal tracts' MTR was lower in the adults with CP. Individuals that had reduced gray matter also tended to have reduced MTR in their corticospinal tracts (r=0.42, p=0.029) and worse hand dexterity clinical scores (r=0.53, p=0.004).
interpretationThese results show that there are changes in the spinal cord microstructure of adults with CP. Ultimately, these microstructural changes play a role in the extent of the hand sensorimotor deficits seen in adults with CP. What this paper adds Adults with cerebral palsy (CP) have a reduced spinal cord cross-sectional area (CSA). Spinal cord gray matter is reduced in adults with CP. Spinal cord CSA is associated with hand dexterity. Magnetization transfer ratio of corticospinal tracts was lower in adults with CP.
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