ArticleEndocrine2021
Is there a role for glycated albumin in the diagnosis of gestational diabetes mellitus?
Article in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Comparison of the ability to diagnose gestational diabetes mellitus between glycated albumin or fructosamine and hemoglobin A1c-a meta-analysis of diagnostic studies.Systematic reviews · 2025Pooled it
- Gestational diabetes mellitus prevalence in Brazil: a systematic review and meta-analysis.Cadernos de saude publica · 2024Pooled it
- Fasting plasma glucose performs better than glycated hemoglobin and glycated albumin for diagnosing gestational diabetes.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Performance of flash continuous glucose monitoring and glycemic marker correlations in Chinese pregnant women with non-type 1 diabetes.World journal of diabetes · 2025Article
- Plasma Glycated Albumin in Early Pregnancy and Gestational Diabetes Mellitus: A Prospective and Longitudinal Study.Diabetes care · 2024Article
- Circulating glycated albumin levels and gestational diabetes mellitus.World journal of diabetes · 2024Article
- Fetal pancreas size and maternal serum biomarkers glycated albumin and insulin-regulated aminopeptidase provide no potential for early prediction of gestational diabetes mellitus.Archives of gynecology and obstetrics · 2023Observational
- Performance of glycated albumin as a biomarker of hyperglycemia in pregnancy: Results from the National Health and Nutrition Examination Survey 1999-2004.Clinical biochemistry · 2023Article
- ROC curves: stats, common sense, and caution.Endocrine · 2022Article
- ROC-curves-fundamentals for proper use.Endocrine · 2022Article
- Hyperglycemia First Detected in Pregnancy in South Africa: Facts, Gaps, and Opportunities.Frontiers in clinical diabetes and healthcare · 2022Review
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies in the general population have advocated glycated albumin (GA) as a useful alternative to glycated haemoglobin (HbA1c) under conditions wherein the latter does not reflect glycaemic status accurately. There are few studies in other populations, especially in pregnant women. Therefore, the aim of this study was to assess the clinical utility of GA in the diagnosis of gestational diabetes mellitus (GDM). MATERIALS AND
methodsThis diagnostic test accuracy study was performed in 149 Brazilian women at 24-28 weeks of gestation referred for an oral glucose tolerance test (OGTT) in a tertiary university hospital. Receiver Operating Characteristic (ROC) curves were used to access the performance of GA and HbA1c in the diagnosis of GDM by the reference OGTT.
resultsGDM by OGTT (IADPSG criteria) was detected in 18.8% of participants. According to ROC analysis, the area under the curve (AUC) for GA was 0.531 (95% CI: 0.405-0.658, p = 0.065) lower than that for HbA1c [0.743 (95% CI: 0.636-0.849; p ≤ 0.001] for the detection of GDM (p = 0.004). The equilibrium cut-off value for GA was 12.6%; sensitivity and specificity in this cut-off point were 53.6% and 54.2%, respectively.
conclusionsGA at 24-28 weeks of gestation does not have ability to correctly discriminate those with and without GDM. In summary, the lack of sensitivity found in our results do not support the solely use of GA in the diagnosis of GDM.
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