Evidence map›Paper›PMID 33718961›Full record

ArticlePain medicine (Malden, Mass.)2021

Pain and the Montreal Cognitive Assessment (MoCA) in Aging.

Josue Cardoso, Brandon Apagueno, Paige Lysne, Lorraine Hoyos, Eric Porges, Joseph L Riley, Roger B Fillingim, Adam J Woods, Ronald Cohen, Yenisel Cruz-Almeida

Open access · greenAbstract read
In one paragraph

Article in Pain medicine (Malden, Mass.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Josue CardosoPain Research & Intervention Center of Excellence, University of Florida, Gainesville, Florida.ORCID 0000-0002-0593-6444
Brandon ApaguenoPain Research & Intervention Center of Excellence, University of Florida, Gainesville, Florida.
Paige LysnePain Research & Intervention Center of Excellence, University of Florida, Gainesville, Florida.
Lorraine HoyosPain Research & Intervention Center of Excellence, University of Florida, Gainesville, Florida.
Eric PorgesCenter for Cognitive Aging & Memory, McKnight Brain Foundation, University of Florida, Gainesville, Florida.
Joseph L RileyPain Research & Intervention Center of Excellence, University of Florida, Gainesville, Florida.
Roger B FillingimPain Research & Intervention Center of Excellence, University of Florida, Gainesville, Florida.
Adam J WoodsCenter for Cognitive Aging & Memory, McKnight Brain Foundation, University of Florida, Gainesville, Florida.
Ronald CohenCenter for Cognitive Aging & Memory, McKnight Brain Foundation, University of Florida, Gainesville, Florida.
Yenisel Cruz-AlmeidaPain Research & Intervention Center of Excellence, University of Florida, Gainesville, Florida.ORCID 0000-0002-0065-0236
University of Florida · USUniversity of Florida Health · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
Supplement-Discovery and Validation of Epigenetic Biomarkers in Brain TissueR01AG067757 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL · 2020 to 2024
$4.2M
Mechanisms of Oxytocin's Analgesia in Older Adults (Diversity Supplement)R01AG059809 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL, EBNER, NATALIE C · 2018 to 2022
$1.8M
Neuroimaging Age-Related Changes i Pain ModulationK01AG048259 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL · 2015 to 2019
$831k
Cognitive and functional deficits associated with reduced cortical GABA in HIV-infected heavy drinkersK01AA025306 · NIAAA · UNIVERSITY OF FLORIDA · PI PORGES, ERIC · 2017 to 2021
$801k
Neuromodulation of Cognition in Older AdultsK01AG050707 · NIA · UNIVERSITY OF FLORIDA · PI WOODS, ADAM J. · 2016 to 2020
$613k
NIAAA NIH HHS K01 AA025306NIA NIH HHS K01 AG048259NIA NIH HHS K01 AG050707NIA NIH HHS P30 AG028740NIA NIH HHS R01 AG059809NIA NIH HHS R01 AG067757
6 · The paper itself

Abstract

objectiveThe present study aimed to determine whether specific cognitive domains part of the Montreal Cognitive Assessment (MoCA) are significantly lower in community-dwelling older adults with chronic pain compared with older adults without pain and whether these domains would be associated with self-reported pain, disability, and somatosensory function.

designSecondary data analysis, cross-sectional.

settingUniversity of Florida. SUBJECTS: Individuals over 60 years old enrolled in the Neuromodulatory Examination of Pain and mobility Across the Lifespan (NEPAL) study were included if they completed the MoCA and other study measures (n = 62). Most participants reported pain on most days during the past three months (63%).

methodsSubjects underwent a health assessment (HAS) and a quantitative sensory testing (QST) session. Health/medical history, cognitive function and self-reported pain measures were administered during the HAS. Mechanical and thermal detection, and thermal pain thresholds were assessed during the QST session.

resultsOlder adults with chronic pain had lower MoCA scores compared with controls on domains of executive function, attention, memory, and language (P < 0.05). The attention and language domains survived adjustments for age, sex, education, depression, and pain duration (P < 0.05). Attention was significantly associated with all pain characteristics including pain intensity and disability, while executive function was associated with mechanical detection (P < 0.05).

conclusionOur results support previous findings that individuals with chronic pain tend to show poorer cognitive functioning compared with pain-free controls in domains of attention and executive function. Our findings also extend these findings to community-dwelling older adults, who are already most vulnerable to age-related cognitive declines.

Indexed as

AgingChronic PainAgedCognitionCross-Sectional StudiesHumansMental Status and Dementia TestsMiddle AgedNeuropsychological TestsAgingCognitionExecutive FunctionPain

Identifiers

PMID33718961
PMCPMC8346915
OpenAlexW3137602147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.