ArticleiScience2021
Automated solubility screening platform using computer vision.
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- From Eyes to Cameras to Kinetics: Computer Vision for Chemical Process Monitoring.Accounts of chemical research · 2026Article
- MODNet: A Monocular Object-Based Depth Estimation Network for AI Robotic Chemists.Precision chemistry · 2026Article
- Steering towards safe self-driving laboratories.Nature reviews. Chemistry · 2025Review
- Efficient discovery of new medicine formulations using a semi-self-driven robotic formulator.Digital discovery · 2025Article
- Solvent Screening for Separation Processes Using Machine Learning and High-Throughput Technologies.Chem & bio engineering · 2025Review
- The Dawn of a New Pharmaceutical Epoch: Can AI and Robotics Reshape Drug Formulation?Advanced healthcare materials · 2024Article
- Self-Driving Laboratories for Chemistry and Materials Science.Chemical reviews · 2024Review
- Accelerating Formulation Design via Machine Learning: Generating a High-throughput Shampoo Formulations Dataset.Scientific data · 2024Article
- An Automated Robotic Interface for Assays: Facilitating Machine Learning in Drug Discovery by the Automation of Physicochemical Property Assays.ACS omega · 2024Article
- Streamlining the automated discovery of porous organic cages.Chemical science · 2024Article
- An integrated high-throughput robotic platform and active learning approach for accelerated discovery of optimal electrolyte formulations.Nature communications · 2024Article
- Computer vision as a new paradigm for monitoring of solution and solid phase peptide synthesis.Chemical science · 2023Article
- Go with the flow: deep learning methods for autonomous viscosity estimations.Digital discovery · 2023Article
- Teaching old presumptive tests new digital tricks with computer vision for forensic applications.Digital discovery · 2023Article
- Rapid planning and analysis of high-throughput experiment arrays for reaction discovery.Nature communications · 2023Article
- Real-Time Automated Solubility Screening Method Using Deep Neural Networks with Handcrafted Features.Sensors (Basel, Switzerland) · 2023Article
- Computer vision for non-contact monitoring of catalyst degradation and product formation kinetics.Chemical science · 2023Article
- Development of Combretastatin A-4 Analogues as Potential Anticancer Agents with Improved Aqueous Solubility.Molecules (Basel, Switzerland) · 2023Article
- Enantioselective synthesis of (-)-tetrabenazineChemical science · 2022Article
- Autonomous Chemical Experiments: Challenges and Perspectives on Establishing a Self-Driving Lab.Accounts of chemical research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Solubility screening is an essential, routine process that is often labor intensive. Robotic platforms have been developed to automate some aspects of the manual labor involved. However, many of the existing systems rely on traditional analytic techniques such as high-performance liquid chromatography, which require pre-calibration for each compound and can be resource consuming. In addition, automation is not typically end-to-end, requiring user intervention to move vials, establish analytical methods for each compound and interpret the raw data. We developed a closed-loop, flexible robotic system with integrated solid and liquid dosing capabilities that relies on computer vision and iterative feedback to successfully measure caffeine solubility in multiple solvents. After initial researcher input (<2 min), the system ran autonomously, screening five different solvent systems (20-80 min each). The resulting solubility values matched those obtained using traditional manual techniques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.