ArticleInternational journal of reproductive biomedicine2021
Effects of monosodium glutamate on testicular structural and functional alterations induced by quinine therapy in rat: An experimental study.
Article in International journal of reproductive biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Germ cell risk assessment of combined exposure to monosodium glutamate and bisphenol A in male SD rat: deciphering the molecular mechanisms.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Protective Effects of Eugenol Against Monosodium Glutamate-Induced Reproductive Toxicity in Male Wistar Rats.Journal of xenobiotics · 2026Article
- Monosodium glutamate is associated with dose-dependent reproductive toxicity and sperm dysfunction in male wistar rats.JBRA assisted reproduction · 2025Article
- Monosodium glutamate exacerbated the lipopolysaccharide-induced reproductive toxicity of male Wistar rats.BMC pharmacology & toxicology · 2025Article
- Rutin andFrontiers in veterinary science · 2025Article
- Phytochemical Evaluation ofAntioxidants (Basel, Switzerland) · 2024Article
- Mitochondrial Differentiation during Spermatogenesis: Lessons fromInternational journal of molecular sciences · 2024Review
- Monosodium Glutamate Intake and Risk Assessment in China Nationwide, and a Comparative Analysis Worldwide.Nutrients · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundQuinine (QU) as an anti-malarial drug induces alterations in testicular tissue. Toxic effects of monosodium glutamate (MSG) on the male reproductive system have been recognized.
objectiveTo investigate the impact of MSG administration on the intensity of gonadotoxicity of QU. MATERIALS AND
methodsSixty eight-wk old Wistar rats weighing 180-200 gr were divided into six groups (n = 10/each): the first group as a control; the second and third groups received low and high doses of MSG (2 & 4 gr/kg i.p.), respectively, for 28 days; the fourth group received QU for seven days (25 mg/kg); and in the fifth and sixth groups, QU was gavaged following the MSG administration (MSG + QU) from day 22 to day 28. Serum testosterone and malondialdehyde (MDA) levels were measured. Testes samples were prepared for tissue MDA levels, histomorphometry, and immunohistochemistry of p53. Sperm analysis was performed on cauda epididymis.
resultsSerum and tissue MDA levels were increased in treated groups compared to the control group. This increment was higher in the MSG + QU groups. The testosterone levels were reduced significantly (p
conclusionThe administration of MSG before and during QU therapy may intensify testicular tissue alterations.
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