ArticleInternational journal of reproductive biomedicine2021
Y chromosome microdeletion and cytogenetic findings in male infertility: A cross-sectional descriptive study.
Article in International journal of reproductive biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 14 citations in OpenAlex.
- The genetic aetiology of male infertility: clinical and forensic implications.Molecular biology reports · 2026Review
- Clinical Analysis of Y Chromosome Microdeletions and Chromosomal Aberrations in 1596 Male Infertility Patients of the Zhuang Ethnic Group in Guangxi.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- A family with normal sperm motility carrying a sY86 deletion in AZFa region and partial deletion in AZFc region.Frontiers in genetics · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfertility affects about 15% of couples worldwide, and the male factor alone is responsible for approximately 50% of the cases. Genetic factors have been found to play important roles in the etiology of azoospermia and severe oligospermia conditions that affect 30% of individuals seeking treatment at infertility clinics.
objectiveTo determine the frequency of chromosomal abnormalities and Y chromosome microdeletion in infertile men. MATERIALS AND
methodsA total of 100 infertile men with abnormal semen parameters were included in this study from 2014 to 2018. Chromosomal analysis was carried out using standard G-banding using Trypsin Giemsa protocol. Multiplex polymerase chain reaction was used to determine the Y microdeletion frequency.
resultsAll participants were aged between 22 and 48 yr with a mean and standard deviation of 35.5
conclusionThe present study emphasizes the importance of routine cytogenetic screening and Y microdeletion assessment for infertile men, which can provide specific and better treatment options before undergoing assisted reproductive technology during genetic counseling.
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