ReviewChronic stress (Thousand Oaks, Calif.)
The Reward System and Post-Traumatic Stress Disorder: Does Trauma Affect the Way We Interact With Positive Stimuli?
Review in Chronic stress (Thousand Oaks, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07664631 (Effects of Stimulant Medications in PTSD), which is not on this map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Stimulant Medications in PTSD
Who cites it
37 citing papers in PubMed.
- Exploring the Role of Reward Functioning in the Overlap of Post-Traumatic Stress and Cocaine Use Disorder.Substance use & misuse · 2025Trial
- Neural Correlates of Maternal Posttraumatic Stress in the First Postpartum Year: Blunted Salience and Prefrontal Responses to Infant Distress.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Early life adversity disrupts adult social reward motivation.bioRxiv : the preprint server for biology · 2026Article
- Neuroimmune mechanisms in PTSD: inflammatory heterogeneity, circuit dysfunction, and biomarker-based subtypes.Molecular biology reports · 2026Review
- Behavioral Domain-Specific Effects of Positive Modulation of α5 and α6 GABAPharmacology research & perspectives · 2026Article
- Review
- Impaired recognition of facial expressions of emotions in refugees: The role of war-related trauma.Journal of traumatic stress · 2026Article
- Physical activity moderates the relationship between PTSD symptom severity and approach-avoidance conflict decision-making.Journal of anxiety disorders · 2025Article
- Physical Activity Is Positively Associated with Model-Based Decision-Making in Pursuit of Reward in Trauma-Exposed Adults.Medicine and science in sports and exercise · 2025Article
- Functional connectivity profiles of amygdala subregions in posttraumatic stress disorder.Translational psychiatry · 2025Article
- Dopamine modulation of basolateral amygdala activity and function.Journal of computational neuroscience · 2025Article
- Climate trauma from wildfire exposure impacts cognitive decision-making.Scientific reports · 2025Article
- Development of a multicomponent survey of experiences of tragedy-based and fear-based trauma in COVID-19 healthcare professionals.Frontiers in psychology · 2025Article
- Modern perspectives on psychoses: dissociation, automatism, and temporality across exogenous and endogenous dimensions.Frontiers in psychiatry · 2025Review
- Designing and developing a prescription digital therapeutic for at-home heart rate variability biofeedback to support and enhance patient outcomes in post-traumatic stress disorder treatment.Frontiers in digital health · 2025Article
- Beyond violence exposure: gender-specific psychological responses to violence in Ecuador - a propensity score analysis.Frontiers in psychiatry · 2025Article
- Does Trauma Change the Way Individuals with Post-Traumatic Stress Disorder (PTSD) Deal with Positive Stimuli?Behavioral sciences (Basel, Switzerland) · 2024Article
- Accumbal Dopamine Responses Are Distinct between Female Rats with Active and Passive Coping Strategies.Biomolecules · 2024Article
- Positive affect modulates memory by regulating the influence of reward prediction errors.Communications psychology · 2024Article
- Enhancing post-traumatic stress disorder patient assessment: leveraging natural language processing for research of domain criteria identification using electronic medical records.BMC medical informatics and decision making · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Post-traumatic stress disorder (PTSD) is a highly prevalent disorder and a highly debilitating condition. Although anhedonia is an important construct of the disorder, the relationship between PTSD and reward functioning is still under-researched. To date, the majority of research on PTSD has focused on fear: fear learning, maintenance, and extinction. Here we review the relevant literature-including clinical observations, self-report data, neuroimaging research, and animal studies-in order to examine the potential effects of post-traumatic stress disorder on the reward system. Our current lack of sufficient insight into how trauma affects the reward system is one possible hindrance to clinical progress. The current review highlights the need for further investigation into the complex relationship between exposure to trauma and the reward system to further our understandings of the ethology of PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.