ArticleCurrent opinion in biomedical engineering2020
Reverse and Forward Engineering Multicellular Structures with Optogenetics.
Article in Current opinion in biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Synthetic budding morphogenesis by optogenetic receptor tyrosine kinase signaling.bioRxiv : the preprint server for biology · 2026Article
- Single-cell analysis and control of microbial systems using optogenetics.Current opinion in microbiology · 2026Review
- Closed-loop optogenetic control of cell biology enables outcome-driven microscopy.Nature communications · 2025Article
- Designer mammalian living materials through genetic engineering.Bioactive materials · 2025Review
- Optogenetic control of apical constriction induces synthetic morphogenesis in mammalian tissues.Nature communications · 2022Article
- Sculpting with stem cells: how models of embryo development take shape.Development (Cambridge, England) · 2021Article
- Stalling interkinetic nuclear migration in curved pseudostratified epithelium of developing cochlea.Royal Society open science · 2021Article
- Modelling the central nervous system: tissue engineering of the cellular microenvironment.Emerging topics in life sciences · 2021Review
- The Art of Engineering Biomimetic Cellular Microenvironments.ACS biomaterials science & engineering · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Understanding how cells self-organize into functional higher-order structures is of great interest, both towards deciphering animal development, as well as for our ability to predictably build custom tissues to meet research and therapeutic needs. The proper organization of cells across length-scales results from interconnected and dynamic networks of molecules and cells. Optogenetic probes provide dynamic and tunable control over molecular events within cells, and thus represent a powerful approach to both dissect and control collective cell behaviors. Here we emphasize the breadth of the optogenetic toolkit and discuss how these methods have already been used to reverse-engineer the design rules of developing organisms. We also offer our perspective on the rich potential for optogenetics to power forward-engineering of tissue assembly towards the generation of bespoke tissues with user-defined properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.