Evidence map›Paper›PMID 33718360›Full record

ArticleFrontiers in cell and developmental biology2021

SARS-CoV-2-Specific Memory T Lymphocytes From COVID-19 Convalescent Donors: Identification, Biobanking, and Large-Scale Production for Adoptive Cell Therapy.

C Ferreras, B Pascual-Miguel, C Mestre-Durán, A Navarro-Zapata, L Clares-Villa, C Martín-Cortázar, R De Paz, A Marcos, J L Vicario, A Balas and 6 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07690943 (A Clinical Study to Evaluate the Safety and Efficacy of Autologous COVID-19 Antigen Specific T Cell Treatment in Prolonged SARS-CoV-2 Infected Patients), which is not on this map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07690943 nacompletednot on this mapstarted 2023, after this paper: background citation

A Clinical Study to Evaluate the Safety and Efficacy of Autologous COVID-19 Antigen Specific T Cell Treatment in Prolonged SARS-CoV-2 Infected Patients

TypeinterventionalSponsorLucasBioRan2023 to 2025Enrolled13ConditionsCOVID-19, COVID-19 (SARS-CoV-2 Infection)ArmsLB-DTK-COV19
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 54 citations in OpenAlex.

  1. Trial
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  14. Familial CD45RAFrontiers in medicine · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Rifampicin for COVID-19.World journal of virology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

C FerrerasHospital La Paz Institute for Health Research, IdiPAZ, University Hospital La Paz, Madrid, Spain.
B Pascual-MiguelHospital La Paz Institute for Health Research, IdiPAZ, University Hospital La Paz, Madrid, Spain.
C Mestre-DuránHospital La Paz Institute for Health Research, IdiPAZ, University Hospital La Paz, Madrid, Spain.
A Navarro-ZapataHospital La Paz Institute for Health Research, IdiPAZ, University Hospital La Paz, Madrid, Spain.
L Clares-VillaHospital La Paz Institute for Health Research, IdiPAZ, University Hospital La Paz, Madrid, Spain.
C Martín-CortázarHospital La Paz Institute for Health Research, IdiPAZ, University Hospital La Paz, Madrid, Spain.
R De PazHematology Department, University Hospital La Paz, Madrid, Spain.
A MarcosHematology Department, University Hospital La Paz, Madrid, Spain.
J L VicarioHistocompatibility, Centro de Transfusión de Madrid, Madrid, Spain.
A BalasHistocompatibility, Centro de Transfusión de Madrid, Madrid, Spain.
F García-SánchezHistocompatibility, Centro de Transfusión de Madrid, Madrid, Spain.
C EguizabalResearch Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.
C SolanoHospital Clínico Universitario de Valencia/Instituto de Investigación Sanitaria INCLIVA, Universidad de Valencia, Valencia, Spain.
M Mora-RilloInfectious Diseases Unit, Internal Medicine Department, Hospital La Paz Institute for Health Research, IdiPAZ, University Hospital La Paz, Madrid, Spain.
B SoriaInstituto de Bioingeniería, Universidad Miguel Hernández de Elche, Alicante, Spain.
A Pérez-MartínezHospital La Paz Institute for Health Research, IdiPAZ, University Hospital La Paz, Madrid, Spain.
Hospital La Paz Institute for Health Research · ESHospital Universitario La Paz · ESOsakidetza · ESUniversitat de Miguel Hernández d'Elx · ESUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Syndrome coronavirus 2 (SARS-CoV-2) pandemic is causing a second outbreak significantly delaying the hope for the virus' complete eradication. In the absence of effective vaccines, we need effective treatments with low adverse effects that can treat hospitalized patients with COVID-19 disease. In this study, we determined the existence of SARS-CoV-2-specific T cells within CD45RA

Indexed as

adoptive cell therapy (ACT)biobankCOVID-19lymphopeniamemory T cells (Tmem)

Identifiers

PMID33718360
PMCPMC7947351
OpenAlexW3130027029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.