Evidence map›Paper›PMID 33718269›Full record

ArticleFrontiers in cellular and infection microbiology2021

Leptin Receptor q223r Polymorphism Influences

Olivia Horrigan, Shinsmon Jose, Anindita Mukherjee, Divya Sharma, Alexander Huber, Rajat Madan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Olfactomedin-4Infection and immunity · 2026
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Olivia HorriganDivision of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Shinsmon JoseDivision of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Anindita MukherjeeDivision of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Divya SharmaDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Alexander HuberDivision of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Rajat MadanDivision of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI James M Wells · 2007 to 2026
$24.4M
Regulation of C. difficile colitis by host genetic and immune factorsR01AI158451 · NIAID · UNIVERSITY OF CINCINNATI · PI MADAN, RAJAT · 2021 to 2025
$2.0M
Role of leptin in mucosal protection during Clostridium difficile infectionK08AI108801 · NIAID · UNIVERSITY OF VIRGINIA · PI MADAN, RAJAT · 2014 to 2018
$880k
Role of a common leptin receptor polymorphism in regulating neutrophil heterogeneity after C. difficile infectionI01BX004630 · VA · CINCINNATI VA MEDICAL CENTER RESEARCH · PI MADAN, RAJAT · 2019 to 2025
–
BLRD VA I01 BX004630NIAID NIH HHS K08 AI108801NIAID NIH HHS R01 AI158451NIDDK NIH HHS P30 DK078392
6 · The paper itself

Abstract

Neutrophils are key first-responders in the innate immune response to

Indexed as

Clostridioides difficileNeutrophilsAnimalsClostridioidesClostridium InfectionsInterleukin-1betaMicePolymorphism, Single NucleotideReceptors, Interleukin-8BReceptors, LeptinCxcr2 protein, mouseIL1B protein, mouseInterleukin-1betaleptin receptor, mouseReceptors, Interleukin-8BReceptors, LeptinClostridioides (C.) difficileCXCR2IL-1βLEPR Q223R gene polymorphismneutrophilia

Identifiers

PMID33718269
PMCPMC7946998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.