ArticleFrontiers in oncology2021
Tumor Molecular Features Predict Endometrial Cancer Patients' Survival After Open or Minimally Invasive Surgeries.
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Laparoscopic surgery is effective and safe in high-risk endometrial cancer.Translational cancer research · 2025Article
- Abnormal p53 High-Grade Endometrioid Endometrial Cancer: A Systematic Review and Meta-Analysis.Cancers · 2024Review
- Clinical characteristics and genomic profiling of outpatients with endometrial cancer at a Chinese tertiary cancer center.Discover oncology · 2024Article
- Review
- Open Surgery including Lymphadenectomy without Adjuvant Therapy for Uterine-Confined Intermediate- and High-Risk Endometrioid Endometrial Carcinoma.Current oncology (Toronto, Ont.) · 2022Article
- The prognostic implication of polymerase epsilon-mutated endometrial cancer.Tzu chi medical journalReview
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Cancer Genome Atlas (TCGA) project shed light on the vital role of tumor molecular features in predicting endometrial cancer patients' prognosis. This study aims to investigate the survival impact of surgical approaches on patients with different genetic alterations.
methods473 endometrial cancer patients from TCGA database were selected. To analyze the prognostic impact of surgical approach, survival analyses were conducted in patients with different molecular features. Finally, a simplified molecular stratification model was established to select patients suitable for open or minimally invasive surgery (MIS).
resultsIn our cohort, 291 patients received open surgery and 182 received MIS. Molecular features influenced patients' survival after different surgical approaches. Based on survival analyses, three molecular subtypes were generated, with subtype 1 harboring
conclusionThe molecular features of endometrial cancer are associated with patients' prognosis after different surgical approaches. MIS should be recommended in patients with
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