Evidence map›Paper›PMID 33718052›Full record

ReviewTranslational lung cancer research2021

Added benefits of early detection of other diseases on low-dose CT screening.

Rowena Yip, Artit Jirapatnakul, Minxia Hu, Xiangmeng Chen, Dan Han, Teng Ma, Yeqing Zhu, Mary M Salvatore, Laurie R Margolies, David F Yankelevitz and 1 more

Abstract readReview
In one paragraph

Review in Translational lung cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Lung cancer screening in Lithuania: a cost-effectiveness analysis.Journal of comparative effectiveness research · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Incidental mediastinal masses detected on chest computed tomography scans during the COVID-19 pandemic.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Long-term outcomes of lung cancer screening in males and females.Lung cancer (Amsterdam, Netherlands) · 2023
    Article
  12. Advances in PET/CT Imaging for Breast Cancer.Journal of clinical medicine · 2023
    Review
  13. Article
  14. Article
  15. Reporting breast density on chest computed tomography.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2023
    Review
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rowena YipDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Artit JirapatnakulDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Minxia HuDepartment of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Xiangmeng ChenDepartment of Radiology, Jiangmen Central Hospital, Jiangmen, China.
Dan HanDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Xicheng District, Beijing, China.
Teng MaDepartment of Radiology, Tong Ren Hospital, Capital Medical University, Beijing, China.
Yeqing ZhuDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mary M SalvatoreDepartment of Radiology, Columbia University Medical Center, New York, NY, USA.
Laurie R MargoliesDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
David F YankelevitzDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Claudia I HenschkeDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-dose CT screening for lung cancer provides images of the entire chest and upper abdomen. While the focus of screening is on finding early lung cancer, radiology leadership has embraced the fact that the information contained in the images presents a new challenge to the radiology profession. Other findings in the chest and upper abdomen were not the reason for obtaining the screening CT scan, nor symptom-prompted, but still need to be reported. Reporting these findings and making recommendations for further workup requires careful consideration to avoid unnecessary workup or interventions while still maximizing the benefit that early identification of these other diseases provided. Other potential findings, such as cardiovascular disease and chronic pulmonary obstructive diseases actually cause more deaths than lung cancer. Existing recommendations for workup of abnormal CT findings are based on symptom-prompted indications for imaging. These recommendations may be different when the abnormalities are identified in asymptomatic people undergoing CT screening for lung cancer. I-ELCAP, a large prospectively collected multi-institutional and multi-national database of screenings, was used to analyze CT findings identified in screening for lung cancer. These analyses and recommendations were made by radiologists in collaboration with clinicians in different medical specialties.

Indexed as

ancillary findingsbreastcardiovascular diseasechronic obstructive pulmonary disease (COPD)Health checklung cancer

Identifiers

PMID33718052
PMCPMC7947380

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.