Evidence map›Paper›PMID 33718033›Full record

ArticleTranslational lung cancer research2021

Delivery of gefitinib with an immunostimulatory nanocarrier improves therapeutic efficacy in lung cancer.

Dingwei Diao, Jianxue Zhai, Jianjun Yang, Hua Wu, Jianjun Jiang, Xiaoying Dong, Antonio Passaro, Beatrice Aramini, Shuan Rao, Kaican Cai

Open access · diamondAbstract read
In one paragraph

Article in Translational lung cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Dingwei DiaoDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jianxue ZhaiDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jianjun YangDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Hua WuDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jianjun JiangDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xiaoying DongDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Antonio PassaroDivision of Thoracic Oncology, European Institute of Oncology, Milan, Italy.
Beatrice AraminiDivision of Thoracic Surgery, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Shuan RaoDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Kaican CaiDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Nanfang Hospital · CNSouthern Medical University · CNEuropean Institute of Oncology · ITUniversity of Modena and Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCombining different cancer treatments represents a promising strategy to improve the therapeutic outcome for lung cancer patients with or without druggable gene alterations.

methodsWe previously developed a polyethylene glycol-based (PEG-based) immunostimulatory nanocarrier (PEG

resultsHere, we report that the delivery of the classical tyrosine kinase inhibitor (TKI), gefitinib, with the optimized PEG

conclusionsOur study therefore demonstrates that delivery of small molecular targeted drugs with the immunostimulatory nanocarrier is a straightforward strategy for improving antitumor response for lung cancer therapy.

Indexed as

Gefitinibimmunostimulatorylung cancernanocarrier

Identifiers

PMID33718033
PMCPMC7947404
OpenAlexW3135135635

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.