Evidence map›Paper›PMID 33717996›Full record

ArticleToxicology reports2021

Evaluation of transporter expression in HK-2 cells after exposure to free and ester-bound 3-MCPD.

Miriam E Mossoba, Mapa S T Mapa, Jessica Sprando, Magali Araujo, Robert L Sprando

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Histamine regulates the activity and the expression of the NaInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Miriam E MossobaU.S. Food and Drug Administration (U.S. FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DT), Laurel, MD, 20817, United States.
Mapa S T MapaU.S. Food and Drug Administration (U.S. FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DT), Laurel, MD, 20817, United States.
Jessica SprandoVirginia-Maryland College of Veterinary Medicine, 205 Duck Pond Road, Blacksburg, VA, 24061, United States.
Magali AraujoU.S. Food and Drug Administration (U.S. FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DT), Laurel, MD, 20817, United States.
Robert L SprandoU.S. Food and Drug Administration (U.S. FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DT), Laurel, MD, 20817, United States.
Center for Food Safety and Applied Nutrition · USUnited States Food and Drug Administration · USVirginia–Maryland College of Veterinary Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3-Monochloropropane-1,2-diol (3-MCPD) is a food processing contaminant in some infant formula products and other foods in the United States. Although rodent studies have demonstrated that 3-MCPD and its palmitic esters have the potential to induce nephrotoxicity, our recent human cell culture studies using the human renal proximal tubule cell line HK-2 have not strongly supported this finding. Considering this disparity, we sought to examine whether changes in transporter gene expression on proximal tubule cells could be modulated by these compounds and allow us to glean mechanistic information on a possible indirect path to proximal tubule injury

Indexed as

1-Li, 1-Linoleoyl-3-chloropropanediol1-Ol, 1-Oleoyl-3-chloropropanediol1-Pa, 1-Palmitoyl-3-chloropropanediol3-MCPD, 3-Monochloropropane-1,2-diol3-Monochloropropane-1,2-diolHK-2HK-2, Human Kidney-2KidneyLi-Li, 1,2-Di-linoleoyl-3-chloropropanediolLi, Linoleic AcidOl-Li, 1-Oleoyl-2-linoleoyl-3-chloropropanediolOl-Ol, 1,2-Di-oleoyl-3-chloropropanediolOl, Oleic AcidPa-Li, 1-Palmitoyl-2-linoleoyl-3-chloropropanediolPa-Ol, 1-Palmitoyl-2-oleoyl-3-chloropropanediolPa-Pa, 1,2-Di-palmitoyl-3-chloropropanediolPa, Palmitic AcidPMA, Phenylmercuric AcetateVAL, Valproic Acid

Identifiers

PMID33717996
PMCPMC7932896
OpenAlexW3129427616

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.