Evidence map›Paper›PMID 33717842›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Mitochondrial Damage-Induced Innate Immune Activation in Vascular Smooth Muscle Cells Promotes Chronic Kidney Disease-Associated Plaque Vulnerability.

Xianjin Bi, Changhong Du, Xinmiao Wang, Xue-Yue Wang, Wenhao Han, Yue Wang, Yu Qiao, Yingguo Zhu, Li Ran, Yong Liu and 8 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 94 citations in OpenAlex.

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  19. Monotropein resists atherosclerosis by reducing inflammation, oxidative stress, and abnormal proliferation and migration of vascular smooth muscle cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Article
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Xianjin BiDepartment of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing Kidney Center of PLA Xinqiao Hospital Army Medical University (Third Military Medical University) Chongqing 400037 China.ORCID https://orcid.org/0000-0002-8481-4305
Changhong DuState Key Laboratory of Trauma Burns and Combined Injury Institute of Combined Injury Chongqing Engineering Research Center for Nanomedicine College of Preventive Medicine Army Medical University (Third Military Medical University) Chongqing 400038 China.ORCID https://orcid.org/0000-0002-1537-0325
Xinmiao WangState Key Laboratory of Trauma Burns and Combined Injury Institute of Combined Injury Chongqing Engineering Research Center for Nanomedicine College of Preventive Medicine Army Medical University (Third Military Medical University) Chongqing 400038 China.ORCID https://orcid.org/0000-0002-1791-3258
Xue-Yue WangLaboratory of Stem Cell & Developmental Biology Department of Histology and Embryology College of Basic Medical Sciences Army Medical University (Third Military Medical University) Chongqing 400038 China.
Wenhao HanDepartment of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing Kidney Center of PLA Xinqiao Hospital Army Medical University (Third Military Medical University) Chongqing 400037 China.
Yue WangDepartment of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing Kidney Center of PLA Xinqiao Hospital Army Medical University (Third Military Medical University) Chongqing 400037 China.
Yu QiaoDepartment of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing Kidney Center of PLA Xinqiao Hospital Army Medical University (Third Military Medical University) Chongqing 400037 China.
Yingguo ZhuDepartment of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing Kidney Center of PLA Xinqiao Hospital Army Medical University (Third Military Medical University) Chongqing 400037 China.ORCID https://orcid.org/0000-0002-1760-6469
Li RanDepartment of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing Kidney Center of PLA Xinqiao Hospital Army Medical University (Third Military Medical University) Chongqing 400037 China.
Yong LiuDepartment of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing Kidney Center of PLA Xinqiao Hospital Army Medical University (Third Military Medical University) Chongqing 400037 China.
Jiachuan XiongDepartment of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing Kidney Center of PLA Xinqiao Hospital Army Medical University (Third Military Medical University) Chongqing 400037 China.
Yinghui HuangDepartment of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing Kidney Center of PLA Xinqiao Hospital Army Medical University (Third Military Medical University) Chongqing 400037 China.
Mingying LiuDepartment of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing Kidney Center of PLA Xinqiao Hospital Army Medical University (Third Military Medical University) Chongqing 400037 China.
Chi LiuDepartment of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing Kidney Center of PLA Xinqiao Hospital Army Medical University (Third Military Medical University) Chongqing 400037 China.
Chunyu ZengDepartment of Cardiology Daping Hospital Army Medical University (Third Military Medical University) Chongqing 400042 China.
Junping WangState Key Laboratory of Trauma Burns and Combined Injury Institute of Combined Injury Chongqing Engineering Research Center for Nanomedicine College of Preventive Medicine Army Medical University (Third Military Medical University) Chongqing 400038 China.
Ke YangDepartment of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing Kidney Center of PLA Xinqiao Hospital Army Medical University (Third Military Medical University) Chongqing 400037 China.ORCID https://orcid.org/0000-0001-9743-8786
Jinghong ZhaoDepartment of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing Kidney Center of PLA Xinqiao Hospital Army Medical University (Third Military Medical University) Chongqing 400037 China.ORCID https://orcid.org/0000-0001-9750-3285
Army Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) is associated with accelerated atherosclerosis progression and high incidence of cardiovascular events, hinting that atherosclerotic plaques in CKD may be vulnerable. However, its cause and mechanism remain obscure. Here, it is shown that apolipoprotein E-deficient (ApoE

Indexed as

atherosclerosischronic kidney diseasecyclic GMP‐AMP synthase‐stimulator of interferon genes pathwayplaque vulnerabilityvascular smooth muscle cell

Identifiers

PMID33717842
PMCPMC7927614
OpenAlexW3119037921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.