ArticleCurrent behavioral neuroscience reports2020
The Role of Intranasal Oxytocin on Social Cognition: An Integrative Human Lifespan Approach.
Article in Current behavioral neuroscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Effects of four-week intranasal oxytocin administration on large-scale brain networks in older adults.Neuropharmacology · 2024Trial
- Effects of chronic intranasal oxytocin on visual attention to faces vs. natural scenes in older adults.Psychoneuroendocrinology · 2024Trial
- Age-dependent effects of oxytocin in brain regions enriched with oxytocin receptors.Psychoneuroendocrinology · 2024Trial
- Intranasal oxytocin modulates the salience network in aging.NeuroImage · 2022Trial
- Safety and tolerability of chronic intranasal oxytocin in older men: results from a randomized controlled trial.Psychopharmacology · 2021Trial
- Sex-specific regulation of social play in juvenile rats by oxytocin neurons in the hypothalamus and oxytocin signaling in the nucleus accumbens.Hormones and behavior · 2026Article
- Interplay of plasma Oxytocin and oxytocin receptor gene methylation levels on empathy in older adults.Scientific reports · 2025Article
- Multisensory integration, brain plasticity and optogenetics in visual rehabilitation.Frontiers in neurology · 2025Review
- Pharmacological Treatment of Cognitive Impairment Associated With Schizophrenia: State of the Art and Future Perspectives.Schizophrenia bulletin open · 2024Article
- Single dose intranasal oxytocin administration: Data from healthy younger and older adults.Data in brief · 2023Article
- Intranasal Oxytocin Modulates Decision-Making Depending on Outcome Predictability-A Randomized Within-Subject Controlled Trial in Healthy Males.Biomedicines · 2022Article
- Oxytocin does not stand alone.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Evaluating the neuropeptide-social cognition link in ageing: the mediating role of basic cognitive skills.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Long term effects of chronic intranasal oxytocin on adult pair bonding behavior and brain glucose uptake in titi monkeys (Plecturocebus cupreus).Hormones and behavior · 2022Article
- Oxytocin's dynamic role across the lifespan.Aging brain · 2022Article
- Age-Related Differences in Amygdala Activation Associated With Face Trustworthiness but No Evidence of Oxytocin Modulation.Frontiers in psychology · 2022Article
- Oxytocin Release Increases With Age and Is Associated With Life Satisfaction and Prosocial Behaviors.Frontiers in behavioral neuroscience · 2022Article
- Chronic oxytocin administration in older men modulates functional connectivity during animacy perception.Aging brain · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
purpose of reviewThis narrative review synthesizes research from the last two decades on the modulatory role of intranasal OT administration (IN-OT) on social cognition in early life, young/middle adulthood, and older adulthood. Advances and knowledge gaps are identified, and future research directions are discussed within an integrative human lifespan framework to guide novel research on IN-OT and social cognition. RECENT
findingsCurrent evidence regarding IN-OT modulation of social-cognitive processes, behavior, and related neurocircuitry is mixed, with some studies suggesting benefits (e.g., improved social perception/interactions, emotion processing) depending on contextual (e.g., social stimuli) and interindividual factors (e.g., age, sex, clinical status). Current research, however, is limited by a focus on isolated life phases, males, and select clinical populations as well as a lack of standardized protocols. SUMMARY: This literature-based reflection proposes that greater generalizability of findings and scientific advancement on social-cognitive modulation via IN-OT require standardized, multi-method, longitudinal, and cross-sequential assessments in well-powered, well-controlled, and representative samples in line with an integrative lifespan approach, which considers development as a lifelong dynamic process involving both change and stability characterized by the interplay between genetic, neurobiological, and socio-behavioral factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.