ArticleJournal of pharmaceutical analysis2021
Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion.
Article in Journal of pharmaceutical analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- Nonexhaustive microextraction as a step toward more sustainable chemical analysis in the field and the clinic.Nature protocols · 2026Review
- Minimally Invasive Chemical Biopsy Needle with Self-Wettable Extraction Phase For In Vivo Tissue Sampling During Medical Procedures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Miniaturised Extraction Techniques in Personalised Medicine: Analytical Opportunities and Translational Perspectives.Molecules (Basel, Switzerland) · 2025Review
- Perspective onJournal of pharmaceutical analysis · 2024Article
- Emerging contaminants: A One Health perspective.Innovation (Cambridge (Mass.)) · 2024Review
- Mapping the metabolic responses to oxaliplatin-based chemotherapy withJournal of pharmaceutical analysis · 2024Article
- SPME as a green sample-preparation technique for the monitoring of phytocannabinoids and endocannabinoids in complex matrices.Journal of pharmaceutical analysis · 2023Review
- [Preparation of sulfonic acid functionalized covalent organic framework solid phase microextraction fibers and their application in the analysis of neurotransmitters in the mouse brain].Se pu = Chinese journal of chromatography · 2023Article
- Monitoring of age- and gender-related alterations of endocannabinoid levels in selected brain regions with the use of SPME probes.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Solid Phase-Based Microextraction Techniques in Therapeutic Drug Monitoring.Pharmaceutics · 2023Review
- Solid-phase microextraction of endogenous metabolites from intact tissue validated using a Biocrates standard reference method kit.Journal of pharmaceutical analysis · 2023Article
- Solid-phase microextraction: a fit-for-purpose technique in biomedical analysis.Analytical and bioanalytical chemistry · 2022Article
- Covalent organic nanospheres as a fiber coating for solid-phase microextraction of genotoxic impurities followed by analysis using GC-MS.Journal of pharmaceutical analysis · 2022Article
- Metabolomic fingerprinting of porcine lung tissue during pre-clinical prolongedJournal of pharmaceutical analysis · 2022Article
- Investigating the Potential Use of Chemical Biopsy Devices to Characterize Brain Tumor Lipidomes.International journal of molecular sciences · 2022Article
- Review
- Metabolomic Phenotyping of Gliomas: What Can We Get with Simplified Protocol for Intact Tissue Analysis?Cancers · 2022Article
- The metabolic fate of oxaliplatin in the biological milieu investigated duringFrontiers in cell and developmental biology · 2022Article
- Dynamic Metabolic Changes During ProlongedFrontiers in immunology · 2022Article
- SPME-LC/MS-based serum metabolomic phenotyping for distinguishing ovarian cancer histologic subtypes: a pilot study.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development of a novel in vivo lung perfusion (IVLP) procedure allows localized delivery of high-dose doxorubicin (DOX) for targeting residual micrometastatic disease in the lungs. However, DOX delivery via IVLP requires careful monitoring of drug level to ensure tissue concentrations of this agent remain in the therapeutic window. A small dimension nitinol wire coated with a sorbent of biocompatible morphology (Bio-SPME) has been clinically evaluated for in vivo lung tissue extraction and determination of DOX and its key metabolites. The in vivo Bio-SPME-IVLP experiments were performed on pig model over various (150 and 225 mg/m
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.