Evidence map›Paper›PMID 33717606›Full record

ArticleImmunometabolism2021

AMPK Metabolism in the B Lineage Modulates Humoral Responses.

Shawna K Brookens, Mark R Boothby

Open access · diamondAbstract read
In one paragraph

Article in Immunometabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Redox regulation of the immune response.Cellular & molecular immunology · 2022
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Shawna K BrookensCancer Biology Program, Vanderbilt University, Nashville, TN 37232, USA.
Mark R BoothbyCancer Biology Program, Vanderbilt University, Nashville, TN 37232, USA.
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

Vanderbilt/Meharry Initiative for Minority Student DvptR25GM062459 · NIGMS · VANDERBILT UNIVERSITY · PI VELEZ EDWARDS, DIGNA R · 2002 to 2020
$10.4M
MULTIDISCIPLINARY BASIC RESEARCH TRAINING IN CANCERT32CA009592 · NCI · VANDERBILT UNIVERSITY · PI Justin M Balko, Julie A Rhoades (Sterling) · 1987 to 2026
$10.4M
Fit to remember? B cell metabolic 'fitness', AMPK & recall antibody responsesR01AI113292 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BOOTHBY, MARK R · 2015 to 2019
$1.9M
Fit to remember? B cell metabolic 'fitness', AMPK & recall antibody responsesR56AI113292 · NIAID · VANDERBILT UNIVERSITY · PI BOOTHBY, MARK R · 2014 to 2014
$393k
NCI NIH HHS T32 CA009592NIAID NIH HHS R01 AI113292NIAID NIH HHS R56 AI113292NIGMS NIH HHS R25 GM062459
6 · The paper itself

Abstract

A large and growing body of evidence supports functions of enzymes that regulate or effect cellular metabolism in governing the development, survival, and effector functions of immune cells-especially T cells, macrophages, and dendritic cells. Among these proteins, adenosine monophosphate-activated protein kinase (AMPK) is a conserved ATP and nutrient sensor that regulates multiple metabolic pathways to promote energy homeostasis. Although AMPK had been shown to regulate aspects of CD4

Indexed as

AMPKB lymphocyteshumoral immunitymemory B cellsmitophagymTORC1plasma cells

Identifiers

PMID33717606
PMCPMC7951989
OpenAlexW3129372385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.