Evidence map›Paper›PMID 33717493›Full record

ArticleCanadian journal of kidney health and disease2021

Cannabis and Cigarette Use Before and After Living Kidney Donation.

Ann Bugeja, Ieta Shams, Sophie Harris, Edward G Clark, Kevin D Burns, Manish M Sood, Ayub Akbari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of kidney health and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ann BugejaDivision of Nephrology, Department of Medicine, Kidney Research Centre, University of Ottawa and The Ottawa Hospital Research Institute, ON, Canada.ORCID https://orcid.org/0000-0002-4106-0451
Ieta ShamsFaculty of Medicine, University of Ottawa, ON, Canada.
Sophie HarrisUniversity of Ottawa, ON, Canada.
Edward G ClarkDivision of Nephrology, Department of Medicine, Kidney Research Centre, University of Ottawa and The Ottawa Hospital Research Institute, ON, Canada.ORCID https://orcid.org/0000-0002-6767-1197
Kevin D BurnsDivision of Nephrology, Department of Medicine, Kidney Research Centre, University of Ottawa and The Ottawa Hospital Research Institute, ON, Canada.
Manish M SoodDivision of Nephrology, Department of Medicine, Kidney Research Centre, University of Ottawa and The Ottawa Hospital Research Institute, ON, Canada.
Ayub AkbariDivision of Nephrology, Department of Medicine, Kidney Research Centre, University of Ottawa and The Ottawa Hospital Research Institute, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is unclear whether kidney donation leads to lifestyle changes in terms of cannabis and cigarette use.

objectiveTo describe cigarette and cannabis use before and after kidney donation and to determine their associations with lifestyle and clinical factors.

designRetrospective cohort study.

settingThe Living Kidney Donor program in the Champlain Local Health Integration Network at The Ottawa Hospital in Ottawa, Canada. PATIENTS: The study included 178 living kidney donors who donated between January 2009 and December 2018. MEASUREMENTS: Donors were screened for cannabis and cigarette use by telephone interview. Their clinical characteristics and changes in kidney function before and after donation were recorded.

methodsCannabis and cigarette use before and after kidney donation were compared using chi-square test. Risk factors associated with their use was examined by univariate and multivariate logistic regression. Wilcoxon rank sum test was used to examine the association of cannabis and Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI) estimated glomerular filtration rate (eGFR) at donation and at last follow-up.

resultsAmong 305 donors, 262 met inclusion criteria and 178 participated (mean of 4.7 ± 2.9 years from kidney donation). Cannabis and cigarette use were reported by 5% (9 of 178) and 13% (23 of 178) at donation. After donation, 8% (14 of 178) and 5% (9 of 178) started cannabis and cigarettes, respectively; 74% (17 of 23) of smokers remained smokers after donation and 88% (53 of 60) who quit smoking before donation did not restart after donation. In multivariate analysis, non-married/common-in-law status was associated with cannabis use (odds ratio, 2.73; 95% confidence interval, 1.05-7.11; LIMITATIONS: The single-center study design limits generalizability. Social desirability bias may have affected survey responses and cigarette smoking was not quantified.

conclusionsCannabis and cigarette use was uncommon in the studied population and was not associated with remaining kidney function. Cannabis use increased post-donation. Most smokers remained smokers after donation and most donors who quit smoking before donation did not restart after donation. This warrants education and support for potential donors who smoke, to quit smoking prior to donation to reduce risks of cardiovascular and end-stage kidney disease.

trial registrationNot applicable as this is not a clinical trial.

Indexed as

cannabiskidney transplantationliving kidney donationsmoking

Identifiers

PMID33717493
PMCPMC7923981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.