Evidence map›Paper›PMID 33717398›Full record

ArticleThe World Allergy Organization journal2021

Chimeric antigen-guiding extracellular vesicles eliminate antigen-specific Th2 cells in subjects with food allergy.

Yuan-Yi Zhang, Li-Hua Mo, Gui Yang, Jiang-Qi Liu, Zhi-Qiang Liu, Li-Teng Yang, Pi-Xin Ran, Zhi-Gang Liu, Ping-Chang Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The World Allergy Organization journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yuan-Yi ZhangDepartment of Respirology & Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Li-Hua MoResearch Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Gui YangDepartment of Otolaryngology, Longgang Central Hospital, Shenzhen, China.
Jiang-Qi LiuDepartment of Allergy, Longgang ENT Hospital & Shenzhen Key Laboratory of ENT, Institute of ENT, Shenzhen, China.
Zhi-Qiang LiuDepartment of Allergy, Longgang ENT Hospital & Shenzhen Key Laboratory of ENT, Institute of ENT, Shenzhen, China.
Li-Teng YangDepartment of Respirology & Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Pi-Xin RanDepartment of Respirology, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Zhi-Gang LiuResearch Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Ping-Chang YangResearch Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Shenzhen University · CNLonggang Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntigen (Ag)-specific T helper (Th)2 cells play a central role in food allergy (FA) pathogenesis. Methods can be used to eliminate Ag-specific Th2 cells that are currently lacking. This study aims to eliminate the Ag-specific Th2 cells with a novel nanoparticle, the mEV (modified extracellular vesicles, that carry a chimeric antigen peptide, MHC II and caspase 3) in a murine FA model.

methodsmEVs were generated by exposing dendritic cells (DC) to ovalbumin (OVA, a specific Ag) and recombinant caspase 3 (Casp3) in the culture overnight. Exosomes were purified from culture supernatant by the magnetic antibody approach. A murine FA model was developed with OVA as the specific Ag.

resultsPurified mEVs had the molecular markers of extracellular vesicle, CD81, CD63, and CD9, cleaved Casp3 and MHC II/OVA complexes. mEVs specifically bound to the surface of Ag-specific CD4

conclusionsmEVs carry Ag/MHC II complexes and Casp3, that can induce Ag-specific Th2 cell apoptosis. Administration of mEV can efficiently suppress experimental FA. The results suggest that the mEVs have the translational potential to be used in the treatment of FA and other allergic diseases.

Indexed as

AllergyApoptosisExtracellular vesicleImmunotherapyNanoparticle

Identifiers

PMID33717398
PMCPMC7918277
OpenAlexW3129433290

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.