Evidence map›Paper›PMID 33717249›Full record

ReviewExperimental and therapeutic medicine2021

The complex relationship between infertility and psychological distress (Review).

Gabriela Simionescu, Bogdan Doroftei, Radu Maftei, Bianca-Elena Obreja, Emil Anton, Delia Grab, Ciprian Ilea, Carmen Anton

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07308561 (The Relationship Between Quality of Life, Anxiety Levels, and Attitudes Toward Artificial Intelligence Among Women Undergoing Infertility Treatment), which is not on this map. Cited by 88 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 5 pooled it
22.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07308561 recruitingnot on this mapstarted 2025, after this paper: background citation

The Relationship Between Quality of Life, Anxiety Levels, and Attitudes Toward Artificial Intelligence Among Women Undergoing Infertility Treatment

TypeobservationalSponsorAcibadem UniversityRan2025 to 2026Enrolled191ConditionsInfertility, Female, Artificial Intelligence, Quality of Life, Anxiety
3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 5 syntheses or guidelines pooled it, 179 citations in OpenAlex.

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  16. The effect of gender role stress on psychological distress in women with breast cancer after mastectomy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Gabriela SimionescuDepartment of Mother and Child Medicine, University of Medicine and Pharmacy 'Gr. T. Popa' Iasi, Faculty of Medicine, 700115 Iasi, Romania.
Bogdan DorofteiDepartment of Mother and Child Medicine, University of Medicine and Pharmacy 'Gr. T. Popa' Iasi, Faculty of Medicine, 700115 Iasi, Romania.
Radu MafteiClinical Department, Clinical Hospital of Obstetrics and Gynecology 'Cuza Voda', 700038 Iasi, Romania.
Bianca-Elena ObrejaFaculty of Letters, Alexandru Ioan Cuza University, 700506 Iasi, Romania.
Emil AntonDepartment of Mother and Child Medicine, University of Medicine and Pharmacy 'Gr. T. Popa' Iasi, Faculty of Medicine, 700115 Iasi, Romania.
Delia GrabDepartment of Mother and Child Medicine, University of Medicine and Pharmacy 'Gr. T. Popa' Iasi, Faculty of Medicine, 700115 Iasi, Romania.
Ciprian IleaDepartment of Mother and Child Medicine, University of Medicine and Pharmacy 'Gr. T. Popa' Iasi, Faculty of Medicine, 700115 Iasi, Romania.
Carmen AntonDepartment of Mother and Child Medicine, University of Medicine and Pharmacy 'Gr. T. Popa' Iasi, Faculty of Medicine, 700115 Iasi, Romania.
Grigore T. Popa University of Medicine and Pharmacy · ROAlexandru Ioan Cuza University · ROClinical Emergency Hospital Bucharest · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infertility is defined as the inability to procreate, or carry or deliver a baby naturally. The majority of specialists describe infertility as being unable to get pregnant after having tried for at least one year. The relationship between infertility and psychological stress is complex. On the one hand, infertile couples are subject to greater stress and have a greater risk of developing psychological disorders compared with normal, healthy couples. On the other hand, high levels of psychological distress have been indicated to increase infertility. Therefore, in the present review, the main factors that may lead to increased stress in couples who try to conceive, psychological stress as the reason for infertility, and the therapies that can help decrease psychological distress and increase chances of pregnancy are underlined. In addition to the psychological side effects that may occur from infertility itself, a range of other side effects can be caused by hormones and drugs used to treat infertility. Additionally, problem during erection and ejaculation can cause of psychological distress, which can lead to infertility among men. Psychotherapy is the main intervention recommended for couples who suffer from any form of infertility. Ideally, counselling should begin before patients start any medical intervention to help with their infertility.

Indexed as

anxietydepressioninfertilitypregnancypsychological distress

Identifiers

PMID33717249
PMCPMC7885086
OpenAlexW3128205378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.