ArticleJournal of drug delivery science and technology2021
Pharmaceutical Co-Crystals, Salts, and Co-Amorphous Systems: A Novel Opportunity of Hot Melt Extrusion.
Article in Journal of drug delivery science and technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Solvent-free synthesis and low-temperature crystal structure of pheno-quinone (the 1:2Acta crystallographica. Section E, Crystallographic communications · 2026Article
- Cocrystal-inspired glycyrrhizic acid-azole nanoassemblies for synergistic biofilm disruption and immune modulation in fungal infections.Journal of nanobiotechnology · 2026Article
- Co-amorphous Approach for Enhancing Rilpivirine Oral Bioavailability using CYP3A4 Inhibitor as a Co-former.AAPS PharmSciTech · 2025Article
- Solid solution quantification from full powder X-ray diffraction profile: novel application of multivariate calibration.Journal of applied crystallography · 2025Article
- Machine learning analysis of pharmaceutical cocrystals solubility parameters in enhancing the drug properties for advanced pharmaceutical manufacturing.Scientific reports · 2025Article
- Stability of Ternary Drug-Drug-Drug Coamorphous Systems Obtained Through Mechanochemistry.Pharmaceutics · 2025Article
- Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation-Where Are We Now?AAPS PharmSciTech · 2024Review
- Amorphous Solid Forms of Ranolazine and Tryptophan and Their Relaxation to Metastable Polymorphs.Crystal growth & design · 2023Article
- Drug complexes: Perspective from Academic Research and Pharmaceutical Market.Pharmaceutical research · 2023Review
- In Situ Co-Amorphization of Olanzapine in the Matrix and on the Coat of Pellets.Pharmaceutics · 2022Article
- Downstream Processing of Amorphous and Co-Amorphous Olanzapine Powder Blends.Pharmaceutics · 2022Article
- Synergistic Effect of Toceranib and Nanohydroxyapatite as a Drug Delivery Platform-Physicochemical Properties and In Vitro Studies on Mastocytoma Cells.International journal of molecular sciences · 2022Article
- Creation of Hydrochlorothiazide Pharmaceutical Cocrystals Via Hot-Melt Extrusion for Enhanced Solubility and Permeability.AAPS PharmSciTech · 2022Article
- Impact of hydrophilic binders on stability of lipid-based sustained release matrices of quetiapine fumarate by the continuous twin screw melt granulation technique.Advanced powder technology : the international journal of the Society of Powder Technology, Japan · 2021Article
- Multicomponent crystalline solid forms of aripiprazole produced via hot melt extrusion techniques: An exploratory study.Journal of drug delivery science and technology · 2021Article
- Coupling hot melt extrusion and fused deposition modeling: Critical properties for successful performance.Advanced drug delivery reviews · 2021Review
- Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals.Pharmaceutics · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Enhancing the solubility of active drug ingredients is a major challenge faced by scientists and researchers. Different approaches have been explored for the enhancement of solubility and physicochemical properties of drugs, without affecting their stability or pharmacological activity. Among the various strategies available, pharmaceutical co-crystals, co-amorphous systems, and pharmaceutical salts as multicomponent systems (MCS) have gained interest to improve physicochemical properties of drugs. Development of MCS by conventional methods involves the utilization of excess amount of solvents, thus, making the product prone to instability, and may also cause harmful side effects in patients. Scale up is critical and involves the investment of huge capital and time. Lately, hot-melt extrusion has been utilized in the development of MCS to enhance solubility, bioavailability, stability, and physicochemical properties of the drugs. In this review, the authors discussed the development of different MCS produced via hot-melt extrusion technology. Specifically, approaches for screening of co-formers and co-crystals, selection of excipients for co-amorphous systems, pharmaceutical salts, and significance of MCS and process parameters affecting product quality are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.