Evidence map›Paper›PMID 33717195›Full record

ArticleFrontiers in immunology2021

COVID-19 Impairs Immune Response to

Dominique Moser, Katharina Biere, Bing Han, Marion Hoerl, Gustav Schelling, Alexander Choukér, Tobias Woehrle

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Overview of Risk Factors and Diagnosis of Invasive Candidiasis.Journal of fungi (Basel, Switzerland) · 2026
    Review
  5. Article
  6. Promising Prodiginins Biological Activities.Chemistry & biodiversity · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogenProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Microbiology and molecular biology reviews : MMBR · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Microorganisms · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Dominique MoserDepartment of Anesthesiology, LMU Hospital, Ludwig-Maximilians-University, Munich, Germany.
Katharina BiereDepartment of Anesthesiology, LMU Hospital, Ludwig-Maximilians-University, Munich, Germany.
Bing HanDepartment of Anesthesiology, LMU Hospital, Ludwig-Maximilians-University, Munich, Germany.
Marion HoerlDepartment of Anesthesiology, LMU Hospital, Ludwig-Maximilians-University, Munich, Germany.
Gustav SchellingDepartment of Anesthesiology, LMU Hospital, Ludwig-Maximilians-University, Munich, Germany.
Alexander ChoukérDepartment of Anesthesiology, LMU Hospital, Ludwig-Maximilians-University, Munich, Germany.
Tobias WoehrleDepartment of Anesthesiology, LMU Hospital, Ludwig-Maximilians-University, Munich, Germany.
Ludwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infection with SARS-CoV-2 can lead to Coronavirus disease-2019 (COVID-19) and result in severe acute respiratory distress syndrome (ARDS). Recent reports indicate an increased rate of fungal coinfections during COVID-19. With incomplete understanding of the pathogenesis and without any causative therapy available, secondary infections may be detrimental to the prognosis. We monitored 11 COVID-19 patients with ARDS for their immune phenotype, plasma cytokines, and clinical parameters on the day of ICU admission and on day 4 and day 7 of their ICU stay. Whole blood stimulation assays with lipopolysaccharide (LPS), heat-killed

Indexed as

AgedAspergillus fumigatusCandida albicansCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedCOVID-19CytokinesDisease SusceptibilityFemaleHumansImmune ToleranceListeria monocytogenesMaleMiddle AgedProgrammed Cell Death 1 ReceptorCytokinesPDCD1 protein, humanProgrammed Cell Death 1 Receptoracute respiratory distress syndromefungallipopolysaccharideListeria monocytogenesSARS-CoV-2second hityeast

Identifiers

PMID33717195
PMCPMC7953065
OpenAlexW3135836198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.