Evidence map›Paper›PMID 33717175›Full record

ArticleFrontiers in immunology2021

ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29.

Wouter J Venema, Sanne Hiddingh, Joke H de Boer, Frans H J Claas, Arend Mulder, Anneke I den Hollander, Efstratios Stratikos, Siranush Sarkizova, Lars T van der Veken, George M C Janssen and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
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  8. Biology of HLA class I associated inflammatory diseases.Best practice & research. Clinical rheumatology · 2024
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  9. Endoplasmic reticulum aminopeptidase 2 regulates CD4Arthritis research & therapy · 2024
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  15. A 69 kb Deletion in chr19q13.42 includingJournal of clinical medicine · 2022
    Article
  16. Article
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  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Wouter J VenemaDepartment of Ophthalmology, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands.
Sanne HiddinghDepartment of Ophthalmology, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands.
Joke H de BoerDepartment of Ophthalmology, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands.
Frans H J ClaasDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Arend MulderDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Anneke I den HollanderDepartment of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands.
Efstratios StratikosDepartment of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Greece.
Siranush SarkizovaDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, United States.
Lars T van der VekenDivision Laboratories, Pharmacy and Biomedical Genetics, Department of Genetics, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands.
George M C JanssenCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands.
Peter A van VeelenCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands.
Jonas J W KuiperDepartment of Ophthalmology, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands.
Leiden University Medical Center · NLUniversity Medical Center Utrecht · NLUtrecht University · NLBroad Institute · USNational and Kapodistrian University of Athens · GRRadboud University Medical Center · NL

Funding

Training Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8M
NHGRI NIH HHS T32 HG002295
6 · The paper itself

Abstract

Birdshot Uveitis (BU) is a blinding inflammatory eye condition that only affects HLA-A29-positive individuals. Genetic association studies linked

Indexed as

AutoimmunityAged, 80 and overAmino Acid MotifsAminopeptidasesAntigen-Presenting CellsAutoantigensBirdshot ChorioretinopathyCell LineFemaleHLA-A AntigensHumansAminopeptidasesAutoantigensERAP2 protein, humanHLA-A29 antigenHLA-A AntigensautoimmunityBirdshotERAP2HLA-A29immunopeptidome

Identifiers

PMID33717175
PMCPMC7950316
OpenAlexW3135087420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.