Evidence map›Paper›PMID 33717140›Full record

ArticleFrontiers in immunology2021

Epigenetic Landscapes of Single-Cell Chromatin Accessibility and Transcriptomic Immune Profiles of T Cells in COVID-19 Patients.

Shun Li, Bin Wu, Yun Ling, Mingquan Guo, Boyin Qin, Xiaonan Ren, Chao Wang, Hua Yang, Lixiang Chen, Yixin Liao and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
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  5. Frontiers in veterinary science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 1 institution in 1 country.

Shun LiDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Bin WuDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yun LingDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Mingquan GuoDepartment of Diagnosis, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Boyin QinDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Xiaonan RenDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Chao WangDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Hua YangDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Lixiang ChenDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yixin LiaoDepartment of Scientific Research, Shanghai Public Health Clinical Center, Shanghai, China.
Yang LiuDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Xiuhua PengDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Chunhua XuDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Zhenyan WangDepartment of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yinzhong ShenDepartment of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jun ChenDepartment of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Li LiuDepartment of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Bowen NiuDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Mengmin ZhuDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Lingling LiuDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Feng LiDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Tongyu ZhuDepartment of Urology, Shanghai Public Health Clinical Center, Shanghai, China.
Zhaoqin ZhuDepartment of Diagnosis, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Xiaohui ZhouDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Hongzhou LuDepartment of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Shanghai Public Health Clinical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T cells play a critical role in coronavirus diseases. How they do so in COVID-19 may be revealed by analyzing the epigenetic chromatin accessibility of cis- and trans-regulatory elements and creating transcriptomic immune profiles. We performed single-cell assay for transposase-accessible chromatin (scATAC) and single-cell RNA (scRNA) sequencing (seq) on the peripheral blood mononuclear cells (PBMCs) of severely ill/critical patients (SCPs) infected with COVID-19, moderate patients (MPs), and healthy volunteer controls (HCs). About 76,570 and 107,862 single cells were used, respectively, for analyzing the characteristics of chromatin accessibility and transcriptomic immune profiles by the application of scATAC-seq (nine cases) and scRNA-seq (15 cases). The scATAC-seq detected 28,535 different peaks in the three groups; among these peaks, 41.6 and 10.7% were located in the promoter and enhancer regions, respectively. Compared to HCs, among the peak-located genes in the total T cells and its subsets, CD4

Indexed as

Calgranulin BCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChromatinClass Ia Phosphatidylinositol 3-KinaseCOVID-19EpigenomeGene Expression ProfilingHumansImmunity, CellularInflammationLymphocyte ActivationNF-KappaB Inhibitor alphaSARS-CoV-2Sequence Analysis, RNASingle-Cell AnalysisCalgranulin BChromatinClass Ia Phosphatidylinositol 3-KinaseNF-KappaB Inhibitor alphaNFKBIA protein, humanPIK3R1 protein, humanS100A9 protein, humanTransposaseschromatin accessibilityCOVID-19SARS-CoV-2scATAC-seqScRNA-seqT cellstranscriptome profiling

Identifiers

PMID33717140
PMCPMC7943924
OpenAlexW3131008232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.