Evidence map›Paper›PMID 33717133›Full record

ArticleFrontiers in immunology2021

AHR Regulates NK Cell Migration

June Ho Shin, Uriel Y Moreno-Nieves, Luhua H Zhang, Chen Chen, Amera L Dixon, Miles H Linde, Emily M Mace, John B Sunwoo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 27 citations in OpenAlex.

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  11. Integrative Analysis ofMolecular imaging and biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

June Ho ShinDepartment of Otolaryngology - Head and Neck Surgery, Stanford Cancer Institute and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Uriel Y Moreno-NievesDepartment of Otolaryngology - Head and Neck Surgery, Stanford Cancer Institute and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Luhua H ZhangDepartment of Otolaryngology - Head and Neck Surgery, Stanford Cancer Institute and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Chen ChenDepartment of Otolaryngology - Head and Neck Surgery, Stanford Cancer Institute and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Amera L DixonDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, United States.
Miles H LindeDepartment of Otolaryngology - Head and Neck Surgery, Stanford Cancer Institute and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Emily M MaceDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, United States.
John B SunwooDepartment of Otolaryngology - Head and Neck Surgery, Stanford Cancer Institute and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Stanford University · USColumbia University Irving Medical Center · US

Funding

Spatial-Genomic Integrative Multi-Species Analysis of Lymph Node MetastasisU54CA209971 · NCI · STANFORD UNIVERSITY · PI NOLAN, GARRY P, PLEVRITIS, SYLVIA KATINA · 2016 to 2021
$11.0M
Reprogramming the Tumor-Immune Interface in Oral CancerR35DE030054 · NIDCR · STANFORD UNIVERSITY · PI JOHN B SUNWOO · 2020 to 2026
$6.7M
DEFINING THE ROLE OF CELL MIGRATION IN HUMAN NK CELL DIFFERENTIATIONR01AI137073 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MACE, EMILY MARGARET · 2018 to 2022
$2.0M
Enhancement of Natural Killer Cell Effector FunctionsR01CA158516 · NCI · STANFORD UNIVERSITY · PI SUNWOO, JOHN B · 2012 to 2016
$1.7M
NCI NIH HHS R01 CA158516NCI NIH HHS U54 CA209971NIAID NIH HHS R01 AI137073NIDCR NIH HHS R35 DE030054
6 · The paper itself

Abstract

Natural killer (NK) cells are effector cells of the innate immune system involved in defense against virus-infected and transformed cells. The effector function of NK cells is linked to their ability to migrate to sites of inflammation or damage. Therefore, understanding the factors regulating NK cell migration is of substantial interest. Here, we show that in the absence of aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, NK cells have reduced capacity to migrate and infiltrate tumors

Indexed as

Cell MovementAnimalsBasic Helix-Loop-Helix ProteinsCell Line, TumorFilaminsHumansKiller Cells, NaturalLymphocytes, Tumor-InfiltratingMiceMice, Inbred C57BLMice, KnockoutMouth NeoplasmsProteasome Endopeptidase ComplexProteolysisReceptors, Aryl HydrocarbonSignal TransductionAhr protein, mouseAsb2 protein, mouseBasic Helix-Loop-Helix ProteinsFilaminsFLNA protein, humanProteasome Endopeptidase ComplexReceptors, Aryl HydrocarbonSuppressor of Cytokine Signaling ProteinsAHRASB2filamin AmigrationNK cellstumor

Identifiers

PMID33717133
PMCPMC7943850
OpenAlexW3129279916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.