Evidence map›Paper›PMID 33717122›Full record

ArticleFrontiers in immunology2021

Safety and Immunogenicity of a 4-Component Toxoid-Based

Arundhathi Venkatasubramaniam, Grant Liao, Eunice Cho, Rajan P Adhikari, Tom Kort, Frederick W Holtsberg, Karen E Elsass, Dean J Kobs, Thomas L Rudge, Keith D Kauffman and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06719219 (A Phase I, Randomized, Double-Blinded and Controlled Trial to Evaluate Safety and Immunogenicity of an Investigational Multicomponent Staphylococcus Aureus Toxoid Vaccine), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06719219 phase1completednot on this mapstarted 2025, after this paper: background citation

A Phase I, Randomized, Double-Blinded and Controlled Trial to Evaluate Safety and Immunogenicity of an Investigational Multicomponent Staphylococcus Aureus Toxoid Vaccine (LTB-SA7) in Healthy Adults.

TypeinterventionalSponsorLimmaTech Biologics AGRan2025 to 2026Enrolled129ConditionsStaphylococcus (S.) Aureus InfectionArmsLTB-SA7, Placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. International journal of molecular sciences · 2022
    Review
  5. Article
  6. Article
  7. Frontiers in immunology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Arundhathi VenkatasubramaniamIntegrated BioTherapeutics, Rockville, MD, United States.
Grant LiaoIntegrated BioTherapeutics, Rockville, MD, United States.
Eunice ChoIntegrated BioTherapeutics, Rockville, MD, United States.
Rajan P AdhikariIntegrated BioTherapeutics, Rockville, MD, United States.
Tom KortIntegrated BioTherapeutics, Rockville, MD, United States.
Frederick W HoltsbergIntegrated BioTherapeutics, Rockville, MD, United States.
Karen E ElsassBatelle - West Jefferson, West Jefferson, OH, United States.
Dean J KobsBatelle - West Jefferson, West Jefferson, OH, United States.
Thomas L RudgeBatelle - West Jefferson, West Jefferson, OH, United States.
Keith D KauffmanLaboratory of Parasitic Diseases, T Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Nickiana E LoraLaboratory of Parasitic Diseases, T Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Daniel L BarberLaboratory of Parasitic Diseases, T Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
M Javad AmanIntegrated BioTherapeutics, Rockville, MD, United States.
Hatice KarauzumIntegrated BioTherapeutics, Rockville, MD, United States.
Integrated BioTherapeutics (United States) · USWest Jefferson Medical Center · USNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · US

Funding

Immune Regulation in Mycobacterial InfectionsZIAAI001171 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARBER, DANIEL · 2012 to 2025
$16.7M
Multivalent Toxoid Vaccine for recurrent Staphylococccus aureus diseaseR01AI111205 · NIAID · INTEGRATED BIOTHERAPEUTICS, INC. · PI M Javad Aman · 2015 to 2026
$6.9M
NIAID NIH HHS HHSN272201200003INIAID NIH HHS R01 AI111205Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntibodies, BacterialAntibody FormationBroadly Neutralizing AntibodiesCD4-Positive T-LymphocytesImmunity, HeterologousImmunogenicity, VaccineLymphocyte ActivationMacaca mulattaMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsStaphylococcal ToxoidStaphylococcal VaccinesSuperantigensVaccinationAntibodies, BacterialBroadly Neutralizing AntibodiesStaphylococcal ToxoidStaphylococcal VaccinesSuperantigensCD4 T cells responseimmunogenicitymulti-componentneutralizing antibodiessafetystaphylococcaltoxoid

Identifiers

PMID33717122
PMCPMC7947289
OpenAlexW3134488415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.