Evidence map›Paper›PMID 33717097›Full record

ArticleFrontiers in immunology2021

IL-7-Adjuvanted Vaginal Vaccine Elicits Strong Mucosal Immune Responses in Non-Human Primates.

Sandrine Logerot, Suzanne Figueiredo-Morgado, Bénédicte Charmeteau-de-Muylder, Abdelkader Sandouk, Anne-Sophie Drillet-Dangeard, Morgane Bomsel, Isabelle Bourgault-Villada, Anne Couëdel-Courteille, Rémi Cheynier, Magali Rancez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Mucosal immunity and vaccine development.Signal transduction and targeted therapy · 2026
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  11. Mucosal vaccines - fortifying the frontiers.Nature reviews. Immunology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sandrine LogerotLaboratory of Dendritic Cells, B Lymphocytes and Cytokines in their Microenvironment During Viral Infections and Cancer, Department of Infection, Immunity and Inflammation, Université de Paris, INSERM, CNRS, Institut Cochin, Paris, France.
Suzanne Figueiredo-MorgadoLaboratory of Dendritic Cells, B Lymphocytes and Cytokines in their Microenvironment During Viral Infections and Cancer, Department of Infection, Immunity and Inflammation, Université de Paris, INSERM, CNRS, Institut Cochin, Paris, France.
Bénédicte Charmeteau-de-MuylderLaboratory of Dendritic Cells, B Lymphocytes and Cytokines in their Microenvironment During Viral Infections and Cancer, Department of Infection, Immunity and Inflammation, Université de Paris, INSERM, CNRS, Institut Cochin, Paris, France.
Abdelkader SandoukLaboratory of Dendritic Cells, B Lymphocytes and Cytokines in their Microenvironment During Viral Infections and Cancer, Department of Infection, Immunity and Inflammation, Université de Paris, INSERM, CNRS, Institut Cochin, Paris, France.
Anne-Sophie Drillet-DangeardLaboratory of Mucosal Entry of HIV-1 and Mucosal Immunity, Department of Infection, Immunity and Inflammation, Université de Paris, INSERM, CNRS, Institut Cochin, Paris, France.
Morgane BomselLaboratory of Mucosal Entry of HIV-1 and Mucosal Immunity, Department of Infection, Immunity and Inflammation, Université de Paris, INSERM, CNRS, Institut Cochin, Paris, France.
Isabelle Bourgault-VilladaLaboratory of Dendritic Cells, B Lymphocytes and Cytokines in their Microenvironment During Viral Infections and Cancer, Department of Infection, Immunity and Inflammation, Université de Paris, INSERM, CNRS, Institut Cochin, Paris, France.
Anne Couëdel-CourteilleLaboratory of Dendritic Cells, B Lymphocytes and Cytokines in their Microenvironment During Viral Infections and Cancer, Department of Infection, Immunity and Inflammation, Université de Paris, INSERM, CNRS, Institut Cochin, Paris, France.
Rémi CheynierLaboratory of Dendritic Cells, B Lymphocytes and Cytokines in their Microenvironment During Viral Infections and Cancer, Department of Infection, Immunity and Inflammation, Université de Paris, INSERM, CNRS, Institut Cochin, Paris, France.
Magali RancezLaboratory of Dendritic Cells, B Lymphocytes and Cytokines in their Microenvironment During Viral Infections and Cancer, Department of Infection, Immunity and Inflammation, Université de Paris, INSERM, CNRS, Institut Cochin, Paris, France.
Inserm · FRUniversité Paris Cité · FRCentre National de la Recherche Scientifique · FRInstitut Cochin · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucosal immune responses are crucial in protecting against pathogens entering through mucosal surfaces. However, due to poor T-cell responsiveness upon mucosal antigenic stimulation, mucosal immunity remains difficult to obtain through vaccines and requires appropriate adjuvants. We previously demonstrated that administered systemically to healthy macaques or locally expressed in the intestinal mucosa of acutely SIV-infected macaques, interleukin-7 (IL-7) triggers chemokine expression and immune cell homing into mucosae, suggesting its important role in the development of mucosal immune responses. We therefore examined whether local delivery of recombinant glycosylated simian IL-7 (rs-IL-7gly) to the vaginal mucosa of rhesus macaques could prepare the lower female genital tract (FGT) for subsequent immunization and act as an efficient mucosal adjuvant. First, we showed that local administration of rs-IL-7gly triggers vaginal overexpression of chemokines and infiltration of mDCs, macrophages, NKs, B- and T-cells in the lamina propria while MamuLa-DR

Indexed as

Adjuvants, ImmunologicImmunity, MucosalAnimalsAntibodies, ViralAntibody FormationBiomarkersChemokinesFemaleHepevirusHost-Pathogen InteractionsImmunizationInterleukin-7Macaca mulattaMucous MembraneSimian Immunodeficiency VirusVaccinesAdjuvants, ImmunologicAntibodies, ViralBiomarkersChemokinesInterleukin-7Vaccineschemokinefemale genital tractinterleukin-7mucosal adjuvantmucosal immune responsesnon-human primatesplasma cellstertiary lymphoid structure

Identifiers

PMID33717097
PMCPMC7947860
OpenAlexW3130954227

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.