Evidence map›Paper›PMID 33717091›Full record

ArticleFrontiers in immunology2021

Polymorphisms and Circulating Plasma Protein Levels of Immune Checkpoints (CTLA-4 and PD-1) Are Associated With Posner-Schlossman Syndrome in Southern Chinese.

Xiaosheng Huang, Xinhua Liu, Ye Ye, Tong Zhang, Shaoyi Mei, Tianhui Zhu, Shiming Peng, Jiamin Cai, Zonghui Yan, Kun Zeng and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Journal of immunology research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Xiaosheng HuangShenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, China.
Xinhua LiuShenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, China.
Ye YeSchool of Ophthalmology, Optometry, Shenzhen Eye Hospital, Shenzhen University, Shenzhen, China.
Tong ZhangShenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, China.
Shaoyi MeiShenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, China.
Tianhui ZhuShenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, China.
Shiming PengShenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, China.
Jiamin CaiSchool of Ophthalmology, Optometry, Shenzhen Eye Hospital, Shenzhen University, Shenzhen, China.
Zonghui YanShenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, China.
Kun ZengShenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, China.
Danyao NieShenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, China.
Liangnan SunShenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, China.
Xiaofeng HouShenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, China.
Jun ZhaoDepartment of Ophthalmology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.
Shenzhen University · CNJinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytotoxic T-lymphocyte associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) are well-known key immune checkpoints that play a crucial dampening effect on regulating T-cell homeostasis and self-tolerance. In this study, we aimed to evaluate the association between immune checkpoints (CTLA-4 and PD-1) and Posner-Schlossman syndrome (PSS) in a southern Chinese population. A total of 137 patients with PSS and 139 healthy controls from a southern Chinese population were recruited. Five single nucleotide polymorphisms (SNPs) of

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseasePolymorphism, Single NucleotideAdultAllelesBiomarkersCase-Control StudiesChinaCTLA-4 AntigenFemaleGene FrequencyGenotypeHaplotypesHumansImmune Checkpoint ProteinsLinkage DisequilibriumBiomarkersCTLA-4 AntigenCTLA4 protein, humanImmune Checkpoint ProteinsProgrammed Cell Death 1 ReceptorCTLA-4genetic variantsPD-1Posner-Schlossman syndromesoluble molecular

Identifiers

PMID33717091
PMCPMC7943469
OpenAlexW3131909193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.