Evidence map›Paper›PMID 33717090›Full record

ArticleFrontiers in immunology2021

FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome.

Chunlin Wang, Klarke M Sample, Babu Gajendran, Philipp Kapranov, Wuling Liu, Anling Hu, Eldad Zacksenhaus, Yanmei Li, Xiaojiang Hao, Yaacov Ben-David

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. UM171 suppresses breast cancer progression by inducing KLF2.Breast cancer research and treatment · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Chunlin WangState Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.
Klarke M SampleThe National Health Commission's Key Laboratory of Immunological Pulmonary Disease, Guizhou Provincial People's Hospital, The Affiliated Hospital of Guizhou University, Guiyang, China.
Babu GajendranState Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.
Philipp KapranovSchool of Biomedical Sciences, Institute of Genomics, Huaqiao University, Xiamen, China.
Wuling LiuState Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.
Anling HuState Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.
Eldad ZacksenhausDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Yanmei LiState Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.
Xiaojiang HaoState Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.
Yaacov Ben-DavidState Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences · CNGuiyang Medical University · CNGuizhou University · CNHuaqiao University · CNUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wiskott-Aldrich Syndrome, WAS/WAVE, is a rare, X-linked immune-deficiency disease caused by mutations in the

Indexed as

AnimalsBase SequenceBiomarkersCell LineChromatin Immunoprecipitation SequencingCytoskeletal ProteinsDisease Models, AnimalDisease SusceptibilityGene Expression RegulationHumansIntracellular Signaling Peptides and ProteinsLeukemiaMiceMice, KnockoutPromoter Regions, GeneticProto-Oncogene Protein c-fli-1BiomarkersCytoskeletal ProteinsFLI1 protein, humanIntracellular Signaling Peptides and ProteinsProto-Oncogene Protein c-fli-1WAS protein, humanWIPF1 protein, humanWiskott-Aldrich Syndrome ProteinFLI1immunodeficiencymegakaryopoiesismicrothrombocytopeniaN-WASPWASPWIPWiskott–Aldrich Syndrome

Identifiers

PMID33717090
PMCPMC7953068
OpenAlexW3135506964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.