Evidence map›Paper›PMID 33717055›Full record

ArticleFrontiers in immunology2020

Submission for Special Issue: The Role of Platelet Activation in the Pathophysiology of HIV, Tuberculosis, and Pneumococcal Disease. Bedaquiline Suppresses ADP-Mediated Activation of Human Platelets

Gregory R Tintinger, Annette J Theron, Helen C Steel, Moloko C Cholo, Jan G Nel, Charles Feldman, Ronald Anderson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Gregory R TintingerDepartment of Internal Medicine, Steve Biko Academic Hospital and Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Annette J TheronDepartment of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Helen C SteelDepartment of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Moloko C CholoDepartment of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Jan G NelDepartment of Haematology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Charles FeldmanDepartment of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Ronald AndersonDepartment of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
University of Pretoria · ZASteve Biko Hospital · ZAUniversity of the Witwatersrand · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although bedaquiline has advanced the treatment of multidrug-resistant tuberculosis (TB), concerns remain about the cardiotoxic potential of this agent, albeit by unexplored mechanisms. Accordingly, we have investigated augmentation of the reactivity of human platelets

Indexed as

Platelet Activation15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAdenosine DiphosphateAdultAntitubercular AgentsCalcium SignalingDiarylquinolinesDose-Response Relationship, DrugEstrenesFemaleHIV InfectionsHumansLong QT SyndromeMaleMiddle AgedPhosphatidylinositol 3-Kinases15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dioneAdenosine DiphosphateAKT1 protein, humanAntitubercular AgentsbedaquilineDiarylquinolinesEstrenesPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProto-Oncogene Proteins c-aktP-SelectinPyrrolidinonesSELP protein, humanThrombinWortmanninadenosine-5′-triphosphatebedaquilinecalcium fluxesCD62Pphosphatidylinositol 3-kinaseplateletswortmannin

Identifiers

PMID33717055
PMCPMC7952968
OpenAlexW3134543240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.