Evidence map›Paper›PMID 33716983›Full record

ArticleFrontiers in endocrinology2021

Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice.

Ryan A Lafferty, Neil Tanday, R Charlotte Moffett, Frank Reimann, Fiona M Gribble, Peter R Flatt, Nigel Irwin

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. The role of PYY in improving insulin resistance.Frontiers in endocrinology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ryan A LaffertySAAD Centre for Pharmacy and Diabetes, Ulster University, Coleraine, United Kingdom.
Neil TandaySAAD Centre for Pharmacy and Diabetes, Ulster University, Coleraine, United Kingdom.
R Charlotte MoffettSAAD Centre for Pharmacy and Diabetes, Ulster University, Coleraine, United Kingdom.
Frank ReimannWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Fiona M GribbleWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Peter R FlattSAAD Centre for Pharmacy and Diabetes, Ulster University, Coleraine, United Kingdom.
Nigel IrwinSAAD Centre for Pharmacy and Diabetes, Ulster University, Coleraine, United Kingdom.
University of Ulster · GBWellcome Trust · GB

Funding

Medical Research Council MC_UU_00014/3Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12012/3Medical Research Council MC_UU_12012/5Wellcome TrustWellcome Trust 106262/Z/14/ZWellcome Trust 106263/Z/14/Z
6 · The paper itself

Abstract

Enzymatically stable and specific neuropeptide Y1 receptor (NPYR1) agonists, such as sea lamprey PYY(1-36) (SL-PYY(1-36)), are believed to improve glucose regulation in diabetes by targeting pancreatic islets. In this study, streptozotocin (STZ) diabetic transgenic

Indexed as

AnimalsBacterial ProteinsBlood GlucoseCell DifferentiationDiabetes Mellitus, ExperimentalGlucagonGlucagon-Secreting CellsInsulinInsulin-Secreting CellsIslets of LangerhansLuminescent ProteinsMiceMice, Inbred C57BLNeuropeptide YPeptidesPetromyzonBacterial ProteinsBlood GlucoseGlucagonInsulinLuminescent ProteinsNeuropeptide YPeptidesStreptozocinyellow fluorescent protein, Bacteriadiabetespeptide YYsea lamprey PYYstreptozotocintransdifferentiation

Identifiers

PMID33716983
PMCPMC7949013
OpenAlexW3134065768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.