Evidence map›Paper›PMID 33716955›Full record

ReviewFrontiers in endocrinology2020

Experimental Approaches for Characterizing the Endocrine-Disrupting Effects of Environmental Chemicals in Fish.

Fritzie T Celino-Brady, Darren T Lerner, Andre P Seale

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 71 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Blood Biochemical Biomarkers in Fish Toxicology-A Review.Animals : an open access journal from MDPI · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Emerging contaminants: A One Health perspective.Innovation (Cambridge (Mass.)) · 2024
    Review
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Fritzie T Celino-BradyDepartment of Human Nutrition, Food and Animal Sciences, University of Hawai'i at Mānoa, Honolulu, HI, United States.
Darren T LernerUniversity of Hawai'i Sea Grant College Program, University of Hawai'i at Mānoa, Honolulu, HI, United States.
Andre P SealeDepartment of Human Nutrition, Food and Animal Sciences, University of Hawai'i at Mānoa, Honolulu, HI, United States.
University of Hawaiʻi at Mānoa · USUniversity of Hawaiʻi Sea Grant · US

Funding

Integrating Osmosensitivity and Autocrine Signaling in a Model for Osmoregulation.R21DK111775 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI SEALE, ANDRE P. · 2016 to 2019
$459k
NIDDK NIH HHS R21 DK111775
6 · The paper itself

Abstract

Increasing industrial and agricultural activities have led to a disturbing increase of pollutant discharges into the environment. Most of these pollutants can induce short-term, sustained or delayed impacts on developmental, physiological, and behavioral processes that are often regulated by the endocrine system in vertebrates, including fish, thus they are termed endocrine-disrupting chemicals (EDCs). Physiological impacts resulting from the exposure of these vertebrates to EDCs include abnormalities in growth and reproductive development, as many of the prevalent chemicals are capable of binding the receptors to sex steroid hormones. The approaches employed to investigate the action and impact of EDCs is largely dependent on the specific life history and habitat of each species, and the type of chemical that organisms are exposed to. Aquatic vertebrates, such as fish, are among the first organisms to be affected by waterborne EDCs, an attribute that has justified their wide-spread use as sentinel species. Many fish species are exposed to these chemicals in the wild, for either short or prolonged periods as larvae, adults, or both, thus, studies are typically designed to focus on either acute or chronic exposure at distinct developmental stages. The aim of this review is to provide an overview of the approaches and experimental methods commonly used to characterize the effects of some of the environmentally prevalent and emerging EDCs, including 17 α-ethinylestradiol, nonylphenol, BPA, phthalates, and arsenic; and the pervasive and potential carriers of EDCs, microplastics, on reproduction and growth.

Indexed as

Age FactorsAnimalsEndocrine DisruptorsEnvironmental ExposureFishesPlasticsReproductionTime FactorsWater Pollutants, ChemicalEndocrine DisruptorsPlasticsWater Pollutants, Chemicalarsenicestrogenic endocrine-disrupting chemicalsgrowthin silicomethodsmicroplasticsplasticizersreproduction

Identifiers

PMID33716955
PMCPMC7947849
OpenAlexW3132034641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.