Evidence map›Paper›PMID 33716756›Full record

ReviewFrontiers in physiology2020

Sodium Transporters in Human Health and Disease.

Kenneth B Gagnon, Eric Delpire

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06641128 (Clinical Study Evaluating the Possible Efficacy and Protective Effect of Empagliflozin in Rheumatoid Arthritis Patients Treated with Methotrexate), which is not on this map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06641128 phase4not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Clinical Study Evaluating the Possible Efficacy and Protective Effect of Empagliflozin in Rheumatoid Arthritis Patients Treated with Methotrexate

TypeinterventionalSponsorTanta UniversityRan2024 to 2025Enrolled44ConditionsRheumatoid Arthritis (RA), Methotrexate Induced Nephrotoxicity, Methotrexate Adverse ReactionArmsMTX SC or IM, Empagliflozin 25mg tab
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 60 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. [Research progress on the pathogenesis and clinical treatment of cirrhotic cardiomyopathy].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  6. Review
  7. Pathophysiology of homocysteine: insights into ion channel dysfunction.Pflugers Archiv : European journal of physiology · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Regulation of epithelial tissue homeostasis by active transepithelial transport.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Metal Ion Signaling in Biomedicine.Chemical reviews · 2025
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kenneth B GagnonDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States.
Eric DelpireDepartment of Anesthesiology, School of Medicine, Vanderbilt University, Nashville, TN, United States.
Southwestern Medical CenterVanderbilt University · US

Funding

WNK-SPAK signaling in the Distal NephronR01DK093501 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, Paul A Welling · 2012 to 2026
$12.1M
OXGR1 in Renal Intercalated Cells, Salt Transport and Diuretic EfficacyR01DK110375 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, SUSAN MARIE WALL · 2017 to 2026
$6.7M
NIDDK NIH HHS R01 DK093501NIDDK NIH HHS R01 DK110375
6 · The paper itself

Abstract

Sodium (Na

Indexed as

cell growthNa+/Ca2+ exchangerNa+ channelsNa-Cl cotransporterNa/Glucose transporterNa+/H+ exchangerNa-K-2Cl cotransporterNa+/K+ pump

Identifiers

PMID33716756
PMCPMC7947867
OpenAlexW3135242080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.