Evidence map›Paper›PMID 33716717›Full record

ArticleFrontiers in aging neuroscience2021

Passive Immunization With a Novel Monoclonal Anti-PrP Antibody TW1 in an Alzheimer's Mouse Model With Tau Pathology.

Allal Boutajangout, Wei Zhang, Justin Kim, Wed Ali Abdali, Frances Prelli, Thomas Wisniewski

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Frontiers in neuroscience · 2022
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Allal BoutajangoutCenter for Cognitive Neurology, New York University Langone Health, New York, NY, United States.
Wei ZhangKey Laboratory of Brain Functional Genomics (Ministry of Education) Shanghai, School of Life Sciences, East China Normal University, Shanghai, China.
Justin KimCenter for Cognitive Neurology, New York University Langone Health, New York, NY, United States.
Wed Ali AbdaliCenter for Cognitive Neurology, New York University Langone Health, New York, NY, United States.
Frances PrelliCenter for Cognitive Neurology, New York University Langone Health, New York, NY, United States.
Thomas WisniewskiCenter for Cognitive Neurology, New York University Langone Health, New York, NY, United States.
NYU Langone Health · USEast China Normal University · CN

Funding

Research Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mary Sherman Mittelman · 2020 to 2026
$28.4M
Transgenic/Behavior CoreP01AG060882 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WISNIEWSKI, THOMAS M · 2020 to 2024
$12.0M
NIA NIH HHS P01 AG060882NIA NIH HHS P30 AG066512
6 · The paper itself

Abstract

Neurofibrillary tangles (NFTs) are a major pathologic hallmark of Alzheimer's disease (AD). Several studies have shown that amyloid β oligomers (Aβo) and tau oligomers mediate their toxicity, in part,

Indexed as

Alzheimer’s diseaseimmunotherapypassive immunizationpriontau related pathologytransgenic mice

Identifiers

PMID33716717
PMCPMC7947695
OpenAlexW3129709723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.