Evidence map›Paper›PMID 33716716›Full record

ArticleFrontiers in aging neuroscience2021

Jagan A Pillai, Gurkan Bebek, Maria Khrestian, James Bena, Cornelia C Bergmann, William S Bush, James B Leverenz, Lynn M Bekris

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Exploring inflammation-related protein expression and its relationship with TSPO PET in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Charting the Next Road Map for CSF Biomarkers in Alzheimer's Disease and Related Dementias.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jagan A PillaiDepartment of Neurology, Cleveland Clinic, Cleveland, OH, United States.
Gurkan BebekCenter for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH, United States.
Maria KhrestianGenomic Medicine Institute, Cleveland Clinic, Cleveland, OH, United States.
James BenaDepartment of Quantitative Health Science, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Cornelia C BergmannDepartment of Neuroscience, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
William S BushDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, United States.
James B LeverenzDepartment of Neurology, Cleveland Clinic, Cleveland, OH, United States.
Lynn M BekrisGenomic Medicine Institute, Cleveland Clinic, Cleveland, OH, United States.
Cleveland Clinic Lerner College of Medicine · USCase Western Reserve University · USCleveland Clinic · USLou Ruvo Brain Institute · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Translational Therapeutics CoreP30AG062428 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI LEVERENZ, JAMES BRUCE · 2019 to 2020
$5.0M
Inflammatory Networks Mediating Cognitive Decline In Preclinical Alzheimers DiseaseK23AG055685 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI PILLAI, JAGAN AYYAPPAN · 2017 to 2021
$916k
NIA NIH HHS K23 AG055685NIA NIH HHS P30 AG062428NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Tumor necrosis factor receptor 2 (TNFR2) promotes neuronal survival downstream. This longitudinal study evaluated whether the

Indexed as

Alzheimer diseasedigit spanexecutive functionMCIneuroinflammationresilienceTNFRSF1B

Identifiers

PMID33716716
PMCPMC7947258
OpenAlexW3131328635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.