ArticleFrontiers in human neuroscience2021
Structural and Functional Changes Are Related to Cognitive Status in Wilson's Disease.
Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Brain microstructural abnormalities in patients with Wilson's disease: A systematic review of diffusion tenor imaging studies.Brain imaging and behavior · 2022Pooled it
- Phenotype-specific white matter microstructural alterations and their clinical correlates in Wilson disease.Scientific reports · 2026Article
- Atrophy related neuroimaging biomarkers for neurological and cognitive function in Wilson disease.Neurological research and practice · 2025Article
- Regional abnormalities in the hippocampus and verbal memory impairment in craniofacial dystonia.Frontiers in neuroscience · 2025Article
- Brain morphometry in hepatic Wilson disease patients.Journal of inherited metabolic disease · 2025Article
- Altered microstructural pattern of the cortex and basal forebrain cholinergic system in wilson's disease: an automated fiber quantification tractography study.Brain imaging and behavior · 2023Article
- Microstructural and functional impairment of the basal ganglia in Wilson's disease: a multimodal neuroimaging study.Frontiers in neuroscience · 2023Article
- Radiomic and clinical nomogram for cognitive impairment prediction in Wilson's disease.Frontiers in neurology · 2023Article
- Dysfunction of the Lenticular Nucleus Is Associated with Dystonia in Wilson's Disease.Brain sciences · 2022Article
- Neuroimaging Correlates of Cognitive Deficits in Wilson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Neuroimaging correlates of brain injury in Wilson's disease: a multimodal, whole-brain MRI study.Brain : a journal of neurology · 2022Article
- Clinical significance of self-descriptive apathy assessment in patients with neurological form of Wilson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with Wilson's disease (WD) suffer from prospective memory (PM) impairment, and some of patients develop cognitive impairment. However, very little is known about how brain structure and function changes effect PM in WD. Here, we employed multimodal neuroimaging data acquired from 22 WD patients and 26 healthy controls (HC) who underwent three-dimensional T1-weighted, diffusion tensor imaging (DTI), and resting state functional magnetic resonance imaging (RS-fMRI). We investigated gray matter (GM) volumes with voxel-based morphometry, DTI metrics using the fiber tractography method, and RS-fMRI using the seed-based functional connectivity method. Compared with HC, WD patients showed GM volume reductions in the basal ganglia (BG) and occipital fusiform gyrus, as well as volume increase in the visual association cortex. Moreover, whiter matter (WM) tracks of WD were widely impaired in association and limbic fibers. WM tracks in association fibers are significant related to PM in WD patients. Relative to HC, WD patients showed that the visual association cortex functionally connects to the thalamus and hippocampus, which is associated with global cognitive function in patients with WD. Together, these findings suggested that PM impairment in WD may be modulated by aberrant WM in association fibers, and that GM volume changes in the association cortex has no direct effect on cognitive status, but indirectly affect global cognitive function by its aberrant functional connectivity (FC) in patients with WD. Our findings may provide a new window to further study how WD develops into cognitive impairment, and deepen our understanding of the cognitive status and neuropathology of WD.
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