Evidence map›Paper›PMID 33716647›Full record

ArticleFrontiers in neuroscience2021

Stimulation and Recording of the Hippocampus Using the Same Pt-Ir Coated Microelectrodes.

Sahar Elyahoodayan, Wenxuan Jiang, Curtis D Lee, Xiecheng Shao, Gregory Weiland, John J Whalen, Artin Petrossians, Dong Song

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Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sahar ElyahoodayanDepartment of Biomedical Engineering, Center for Neural Engineering, University of Southern California, Los Angeles, CA, United States.
Wenxuan JiangDepartment of Biomedical Engineering, Center for Neural Engineering, University of Southern California, Los Angeles, CA, United States.
Curtis D LeeEpic Medical, Inc., Pasadena, CA, United States.
Xiecheng ShaoDepartment of Biomedical Engineering, Center for Neural Engineering, University of Southern California, Los Angeles, CA, United States.
Gregory WeilandEpic Medical, Inc., Pasadena, CA, United States.
John J WhalenEpic Medical, Inc., Pasadena, CA, United States.
Artin PetrossiansEpic Medical, Inc., Pasadena, CA, United States.
Dong SongDepartment of Biomedical Engineering, Center for Neural Engineering, University of Southern California, Los Angeles, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Same-electrode stimulation and recording with high spatial resolution, signal quality, and power efficiency is highly desirable in neuroscience and neural engineering. High spatial resolution and signal-to-noise ratio is necessary for obtaining unitary activities and delivering focal stimulations. Power efficiency is critical for battery-operated implantable neural interfaces. This study demonstrates the capability of recording single units as well as evoked potentials in response to a wide range of electrochemically safe stimulation pulses through high-resolution microelectrodes coated with co-deposition of Pt-Ir. It also compares signal-to-noise ratio, single unit activity, and power efficiencies between Pt-Ir coated and uncoated microelectrodes. To enable stimulation and recording with the same microelectrodes, microelectrode arrays were treated with electrodeposited platinum-iridium coating (EPIC) and tested in the CA1 cell body layer of rat hippocampi. The electrodes' ability to (1) inject a large range of electrochemically reversable stimulation pulses to the tissue, and (2) record evoked potentials and single unit activities were quantitively assessed over an acute time period. Compared to uncoated electrodes, EPIC electrodes recorded signals with higher signal-to-noise ratios (coated: 9.77 ± 1.95 dB; uncoated: 1.95 ± 0.40 dB) and generated lower voltages (coated: 100 mV; uncoated: 650 mV) for a given stimulus (5 μA). The improved performance corresponded to lower energy consumptions and electrochemically safe stimulation above 5 μA (>0.38 mC/cm

Indexed as

electrochemistryelectrophysiologyintracortical recordingintracortical stimulationPt-Ir electrodeposition

Identifiers

PMID33716647
PMCPMC7943859

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.