Evidence map›Paper›PMID 33716550›Full record

ArticleBiochemical engineering journal2021

Characterization of PMI-5011 on the Regulation of Deubiquitinating Enzyme Activity in Multiple Myeloma Cell Extracts.

Manibarathi Vaithiyanathan, Yongmei Yu, Alireza Rahnama, Jacob H Pettigrew, Nora Safa, Dong Liu, Ted J Gauthier, Z Elizabeth Floyd, Adam T Melvin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical engineering journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Manibarathi VaithiyanathanCain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA, 70803.
Yongmei YuPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808.
Alireza RahnamaCain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA, 70803.
Jacob H PettigrewCain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA, 70803.
Nora SafaCain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA, 70803.
Dong LiuLSU AgCenter School of Plant, Environmental and Soil Sciences, Louisiana State University, Baton Rouge, LA, 70803.
Ted J GauthierLSU AgCenter School of Plant, Environmental and Soil Sciences, Louisiana State University, Baton Rouge, LA, 70803.
Z Elizabeth FloydPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808.
Adam T MelvinCain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA, 70803.
Louisiana State University · USLouisiana State University Agricultural Center · USLouisiana State University System · US

Funding

Pregnane and Glycosides and Obesity/llya RaskinP50AT002776 · NCCIH · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RASKIN, ILYA · 2005 to 2019
$24.9M
NCCIH NIH HHS P50 AT002776
6 · The paper itself

Abstract

Deubiquitinating enzyme (DUB)-targeted therapeutics have shown promise in recent years as alternative cancer therapeutics, especially when coupled with proteasome-based inhibitors. While a majority of DUB-based therapeutics function by inhibiting DUB enzymes, studies show that positive regulation of these enzymes can stabilize levels of protein degradation. Unfortunately, there are currently no clinically available therapeutics for this purpose. The goal of this work was to understand the effect of a botanical extract from

Identifiers

PMID33716550
PMCPMC7949241
OpenAlexW3096773972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.